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Your search keyword '"Xue-Yu, Hu"' showing total 3 results
Start Over Author "Xue-Yu, Hu" Topic spinal cord injury
3 results on '"Xue-Yu, Hu"'

1. Photobiomodulation provides neuroprotection through regulating mitochondrial fission imbalance in the subacute phase of spinal cord injury

Author

Xin Li, Xuan-Kang Wang, Zhi-Jie Zhu, Zhuo-Wen Liang, Peng-Hui Li, Yang-Guang Ma, Tan Ding, Kun Li, Xiao-Shuang Zuo, Cheng Ju, Zhi-Hao Zhang, Zhi-Wen Song, Hui-Lin Quan, Jia-Wei Zhang, Liang Luo, Zhe Wang, and Xue-Yu Hu

Subjects
low-level laser therapy, mitochondria, mitochondrial dynamics, mitochondrial fission imbalance, neuron, photobiomodulation, secondary injury, spinal cord injury, Neurology. Diseases of the nervous system, RC346-429
Abstract

Increasing evidence indicates that mitochondrial fission imbalance plays an important role in delayed neuronal cell death. Our previous study found that photobiomodulation improved the motor function of rats with spinal cord injury. However, the precise mechanism remains unclear. To investigate the effect of photobiomodulation on mitochondrial fission imbalance after spinal cord injury, in this study, we treated rat models of spinal cord injury with 60-minute photobiomodulation (810 nm, 150 mW) every day for 14 consecutive days. Transmission electron microscopy results confirmed the swollen and fragmented alterations of mitochondrial morphology in neurons in acute (1 day) and subacute (7 and 14 days) phases. Photobiomodulation alleviated mitochondrial fission imbalance in spinal cord tissue in the subacute phase, reduced neuronal cell death, and improved rat posterior limb motor function in a time-dependent manner. These findings suggest that photobiomodulation targets neuronal mitochondria, alleviates mitochondrial fission imbalance-induced neuronal apoptosis, and thereby promotes the motor function recovery of rats with spinal cord injury.

Published
2023
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3. Low-level laser facilitates alternatively activated macrophage/microglia polarization and promotes functional recovery after crush spinal cord injury in rats

Author

Zhe Wang, Xue Yu Hu, Chen Dai, Xue Feng Shen, Ji Wei Song, Zhuo Wen Liang, Shuang Wang, Kun Li, and Yu Ze Gong

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Science, Inflammation, Neuroprotection, Article, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Spinal cord injury, Spinal Cord Injuries, Neuroinflammation, Interleukin 4, Neurons, Multidisciplinary, Behavior, Animal, Microglia, medicine.diagnostic_test, business.industry, Macrophages, Recovery of Function, Macrophage Activation, medicine.disease, Rats, Disease Models, Animal, Phenotype, 030104 developmental biology, medicine.anatomical_structure, Astrocytes, Interleukin 13, Cytokines, Medicine, Laser Therapy, Inflammation Mediators, medicine.symptom, business, Biomarkers, 030217 neurology & neurosurgery
Abstract

Macrophages and resident microglia play an import role in the secondary neuroinflammation response following spinal cord injury. Reprogramming of macrophage/microglia polarization is an import strategy for spinal cord injury restoration. Low-level laser therapy (LLLT) is a noninvasive treatment that has been widely used in neurotrauma and neurodegenerative diseases. However, the influence of low-level laser on polarization of macrophage/microglia following spinal cord injury remains unknown. The present study applied low-level laser therapy on a crush spinal cord injury rat model. Using immunofluorescence, flow cytometry, RT-qPCR, and western blot assays, we found that low-level laser therapy altered the polarization state to a M2 tendency. A greater number of neurons survived in the pare injury site, which was accompanied by higher BBB scores in the LLLT group. Furthermore, low-level laser therapy elevated expression of interleukin 4 (IL-4) and interleukin 13 (IL-13). Results from this study show that low-level laser therapy has the potential for reducing inflammation, regulating macrophage/microglia polarization, and promoting neuronal survival. These beneficial effects demonstrate that low-level laser therapy may be an effective candidate for clinical treatment of spinal cord injury.

Published
2017

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