1. p16 Overexpression in Sinonasal Squamous Cell Carcinoma: Association with Human Papillomavirus and Prediction of Survival Outcomes.
- Author
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Hirakawa, Hitoshi, Ikegami, Taro, Touyama, Masatomo, Ooshiro, Yurika, Higa, Tomoyo, Higa, Teruyuki, Agena, Shinya, Kinjyo, Hidetoshi, Kondo, Shunsuke, Kise, Norimoto, Tanaka, Katsunori, Maeda, Hiroyuki, Tamaki, Tomoko, Wada, Naoki, and Suzuki, Mikio
- Subjects
HUMAN papillomavirus ,SQUAMOUS cell carcinoma ,SURVIVAL rate ,GENETIC overexpression ,PARANASAL sinuses - Abstract
p16 overexpression is often used as a surrogate marker for human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma but remains an uncertain diagnostic tool for HPV-related sinonasal squamous cell carcinoma (SNSCC). Our study involved 79 consecutive SNSCC patients who were treated at a tertiary referral university hospital during 2006–2021. We retrospectively examined their clinical characteristics and conducted p16 immunohistochemistry and HPV detection. We found that 12.7% of the patients exhibited p16 overexpression, which was significantly more common in the nasal cavity and increased from 2015 onward. The HPV was a high-risk type and viral loads ranged from 4.2 to 1.6 × 10
6 copies/ng DNA with genome integration. Five-year overall survival (OS) and five-year relapse-free survival (RFS) rates were 74.6% and 69.9%, respectively. Our multivariate analysis showed that T category (T1–4a) and hemoglobin levels (≥13.7) were significant favorable prognostic factors for OS, while T category, performance status, and p16 overexpression were significantly associated with RFS. In patients with p16 overexpression, OS was 100% and RFS was 90%. Our findings suggest that p16 overexpression is a reliable surrogate marker for transcriptionally active HPV infection and predicts a favorable prognosis. [ABSTRACT FROM AUTHOR]- Published
- 2023
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