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Understanding groundwater flow is essential for quantifying recharge and identifying relevant processes in an aquifer. Hydrogeochemical models have proven to be successful in identifying origin and processes during water recharge. We integrated the hydrogeochemistry, environmental isotopes and CFC technique to develop a conceptual and a groundwater mixing model of the Amazcala aquifer in Central Mexico. Results demonstrate that groundwater recharge consists of local meteoric recharge and a regional geothermal input. The local resident groundwater component represents the primary source of groundwater contributing with an average of 56% (σ = 0.07). The second crucial component of groundwater is the contribution of the local meteoric component contribution with averages to 23% (σ = 0.05). The third component is the regional geothermal component, which on average contributes to 21% (σ = 0.03). Regional geothermal influence has been reported in several aquifers in volcanic regions. This geothermal input influences volcanic aquifers located in the Trans-Mexican Volcanic Belt and should be considered in the water balance budget. Excessive groundwater extraction raises the vulnerability of the aquifer to natural and/or anthropogenic pollution, affecting the quality of water. Understanding the hydrogeological system offers a useful framework for developing and executing Managed Aquifer Recharge strategies (MAR). • We present a hydrogeological model with the delineation of three aquifer reservoirs and their geological settings. • Geochemistry was also used to infer source region and hydrochemical processes control groundwater composition. • We quantified the groundwater mixing ratios of the recharge water from the different geological reservoirs. • The recent meteoric recharge was dated and quantified using CFC's and SF 6 approach. • Results demonstrate the importance of multidisciplinary approach for Managed Aquifer Recharge in the semi-arid region. [ABSTRACT FROM AUTHOR]