1. Contemporary evaluation of acute myeloid leukemia patients with long‐term survival exceeding 5 years.
- Author
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Heering, Gabriel, Sasson, Maya, Dominissini, Dan, Shimoni, Avichai, Avigdor, Abraham, Nagler, Arnon, and Canaani, Jonathan
- Subjects
ACUTE myeloid leukemia ,STEM cell transplantation ,INDUCTION chemotherapy ,REMISSION induction ,PATIENTS' attitudes - Abstract
Objectives: Define clinical and laboratory attributes of acute myeloid leukemia (AML) patients with long‐term survival exceeding five years and compare them with AML patients succumbing to disease within 2 years of diagnosis. Methods: A retrospective analysis of AML patients alive at least five years from the time of initial diagnosis. Baseline clinical data were compared with patients who died within 2 years of diagnosis. Results: The long‐term cohort consisted of 93 patients treated in 2007–2016 with a median follow‐up duration of 7.7 years (range 5–13.6 years). European LeukemiaNet (ELN) 2017 favorable risk patients accounted for 60% of the cohort. All long‐term survivors achieved remission following induction chemotherapy. Multivariate analysis showed that compared with 132 patients experiencing death within 2 years of diagnosis, long‐term survivors were more likely to be of younger age [odds ratio (OR), 0.92; 95% confidence interval (CI), 0.9–0.95; p < 0.001], have a lower initial WBC count (OR, 0.58; 95% CI, 0.43–0.79; p = 0.0004), undergo an allogeneic stem cell transplantation (OR, 7.95; 95% CI, 3.07–20.59; p < 0.0001), and harbor favorable risk cytogenetics (OR, 0.03; 95% CI, 0.006–0.23; p = 0.0004). Conclusions: Long‐term survival of AML is seen in a distinct demographic and biologic patient subset. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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