1. Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H 2 O 2 -induced myocardial cell injury
- Author
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Chen-Mei Mao, Shilin Yang, Yanli Liu, Shan-Shan Li, and Qiong-Ming Xu
- Subjects
biology ,010405 organic chemistry ,Chemistry ,Stereochemistry ,DPPH ,General Medicine ,Ilex cornuta ,Aquifoliaceae ,biology.organism_classification ,01 natural sciences ,Chemical reaction ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Triterpenoid ,Complementary and alternative medicine ,Drug Discovery ,Myocardial cell ,Organic chemistry ,Scavenging ,Two-dimensional nuclear magnetic resonance spectroscopy - Abstract
In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside (1), 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (2), and urs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (3), and a known triterpenoid, 3β-hydroxy-urs-2, 18-dien-28-oic acid (4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical scavenging activity. more...
- Published
- 2017
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