1. Biphenyl-type neolignans with NO inhibitory activity from the fruits of Magnolia tripetala
- Author
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Zhen-Xiang Liu, Xing-De Wu, Lin-Fen Ding, Jin-Da Li, Tie Lei, Liu-Dong Song, and Wei Nie
- Subjects
Biphenyl ,biology ,Chemistry ,Stereochemistry ,Dimer ,chemistry.chemical_element ,Plant Science ,Magnolia tripetala ,biology.organism_classification ,Biochemistry ,chemistry.chemical_compound ,Ic50 values ,Agronomy and Crop Science ,Carbon ,Two-dimensional nuclear magnetic resonance spectroscopy ,Biotechnology - Abstract
Tripetalins A (1) and B (2), two new biphenyl-type neolignans were obtained from the fruits of Magnolia tripetala, along with four known analogues. The structures of the new compounds were characterized by comprehensive spectroscopic analyses including 1H, 13C, and 2D NMR, IR, and HRESIMS data. Tripetalin A (1) was the first magnolol-honokiol-type neolignan dimer linked through C-5′‒C5′′ carbon bond. Magnoquinone (5) and magnotriol B (6) displayed remarkable NO inhibitory activity with IC50 values of 4.52 ± 0.07 and 2.02 ± 0.03 μM, respectively.
- Published
- 2021