1. Targeted therapy in gastric cancer.
- Author
-
Thiel A and Ristimäki A
- Subjects
- Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Antineoplastic Agents therapeutic use, Clinical Trials as Topic, ErbB Receptors antagonists & inhibitors, Hepatocyte Growth Factor antagonists & inhibitors, Humans, Molecular Targeted Therapy trends, Proto-Oncogene Proteins c-met antagonists & inhibitors, Receptor, ErbB-2 antagonists & inhibitors, Stomach Neoplasms metabolism, TOR Serine-Threonine Kinases antagonists & inhibitors, Trastuzumab, Vascular Endothelial Growth Factor Receptor-2 antagonists & inhibitors, Ramucirumab, Molecular Targeted Therapy methods, Stomach Neoplasms therapy
- Abstract
Gastric cancer is often diagnosed at an advanced stage. Although chemotherapy prolongs survival and improves quality of life, the survival of gastric cancer patients with advanced disease is short. Thanks to recent insights into the molecular pathways involved in gastric carcinogenesis, new targeted treatment options have become available for gastric cancer patients. Trastuzumab, an antibody targeted to HER-2, was shown to improve survival of advanced gastric cancer patients harboring HER-2 overexpression due to gene amplification in their tumor cells, and is currently also explored in adjuvant and neoadjuvant settings. Another agent with promising results in clinical trials is ramucirumab, an antibody targeting VEGFR-2. No clear survival benefit, however, were experienced with agents targeting EGFR (cetuximab, panitumumab), VEGF-A (bevacizumab), or mTOR (everolimus). Drugs targeting c-MET/HGF are currently under investigation in biomarker-selected cohorts, with promising results in early clinical trials. This review will summarize the current status of targeted treatment options in gastric cancer., (© 2015 APMIS. Published by John Wiley & Sons Ltd.)
- Published
- 2015
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