1. [The effect of cerebrolysin in dosage 50 ml on the volume of lesion in ischemic stroke].
- Author
-
Shamalov NA, Stakhovskaia LV, Burenchev DV, Kichuk IV, Tvorogova TV, Botsina AIu, Smychkov AS, Kerbikov OB, Moessler H, Novak P, and Skvortsova VI
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Treatment Outcome, Amino Acids administration & dosage, Neuroprotective Agents administration & dosage, Stroke drug therapy, Stroke pathology
- Abstract
The purpose of this randomized, double-blind, placebo-controlled study was to assess safety and efficacy of cerebrolysin used in dosage 50 ml in acute ischemic stroke. Forty-seven patients with ischemic stroke, aged 45-85 years, who were admitted to a clinical unit within the first 12 h after stroke onset were included in the study. A quantitative time-related MRI analysis of the dynamics of neurological deficit revealed the more rapid decrease of stroke volume to the 28th day in the group treated with cerebrolysin (45.4% versus 43.6% in the placebo-group (p < 0.05)). No side-effects of treatment with cerebrolysin was found. The results of this prospective, randomized, placebo-controlled study suggest the positive effect of cerebrolysin on the dynamics of volume lesion in patients with ischemic stroke.
- Published
- 2010