Search

Background: We examined the correlation of angiographic collaterals in acute stroke with the presence, extent, and distribution of white matter changes, so-called Leukoaraiosis, in an effort to determine if Leukoaraiosis indicates chronic cerebral hypoperfusion and/or is associated with the development of cerebral collateral circulation., Methods: Consecutive acute strokes due to large-vessel occlusion on angiography had preprocedure CT or MRI white matter changes graded utilizing the Fazekas scale incorporating deep and periventricular components. Angiographic collaterals evaluated with a 5-point scale were correlated with leukoaraiosis., Results: Collaterals were evaluated in 102 cases (51 men, 51 women; mean age 66 (SD 18) years with acute occlusions of the proximal middle cerebral artery (MCA) (47%), distal internal carotid artery (ICA) (28%), distal MCA (9%), basilar (7%), proximal ICA (7%), vertebral (1%), posterior cerebral artery (PCA) (1%), and common carotid artery (CCA) (1%). Collateral grade was well distributed across the scale. Periventricular and deep white matter changes were evident in 34% and 51% of cases, respectively. Collateral grade exhibited no relationship with either the presence or extent of periventricular disease (P= .772, r= .029) or deep white matter changes (P= .559, r=-.059)., Conclusions: Leukoaraisosis exhibits no overt relationship with the extent of collaterals measured at angiography in acute ischemic stroke. Chronic small-vessel disease may be a distinct pathophysiologic entity unrelated to arteriogenesis and compensatory aspects of collateral flow., (© 2010 by the American Society of Neuroimaging.)

Background and Purpose: Selective nonpublication will yield publication bias and a published literature imperfectly representative of the full range of scientific findings. We evaluated the proportion of research abstracts presented at the leading United States research meeting in stroke, the International Stroke Conference (ISC), which were subsequently published as full-length articles and investigated the factors associated with full manuscript publication., Methods: Features of all abstracts presented at the annual ISC meeting in February 2000 were analyzed. Search of the National Library of Medicine PubMed database and written communication with abstract authors was performed to determine conversion of abstracts to fully published manuscripts over the subsequent 5 years., Results: Among the 353 abstracts presented at the 2000 International Stroke Conference, 108 were oral presentations and 245 posters. Overall, 202/353 (62.3%) resulted in full-length publications, with a median time to publication of 15 months. In multivariate analysis, factors increasing likelihood of full-length publication were: platform rather than poster presentations (odds ratio [OR] 3.0, 95% CI, 1.6 to 5.5), authors with a university affiliation (OR 2.2, 95% CI, 1.2 to 4.1), and European region of origin (OR 2.2, 95% CI, 1.1 to 4.4), whereas topic concerning community/risk factors decreased the likelihood of publication (OR 0.3, 95% CI, 0.16 to 0.74). Positive results, multicenter collaboration and industry sponsorship did not affect publication rate., Conclusions: Approximately 1 of every 3 abstracts presented at an international stroke meeting was not published as a full manuscript within 5 years. Poster abstracts were less likely to be published in full manuscript form than oral presentations.