1. Prognostic value of morning surge of blood pressure in middle-aged treated hypertensive patients.
- Author
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Coccina F, Pierdomenico AM, Cuccurullo C, Vitulli P, Pizzicannella J, Cipollone F, and Pierdomenico SD
- Subjects
- Antihypertensive Agents therapeutic use, Female, Follow-Up Studies, Humans, Italy epidemiology, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Factors, Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome epidemiology, Blood Pressure Monitoring, Ambulatory methods, Blood Pressure Monitoring, Ambulatory statistics & numerical data, Heart Failure diagnosis, Heart Failure epidemiology, Hypertension diagnosis, Hypertension drug therapy, Hypertension epidemiology, Stroke diagnosis, Stroke epidemiology
- Abstract
We investigated the prognostic value of morning surge (MS) of blood pressure (BP) in middle-aged treated hypertensive patients. The occurrence of a composite end point (coronary events, stroke, and heart failure requiring hospitalization) was evaluated in 1073 middle-aged treated hypertensive patients (mean age 49 years). Patients with preawakening MS of BP above the 90th percentile (27/20.5 mm Hg for systolic/diastolic BP) were defined as having high MS of BP. During the follow-up (mean 10.9 years), 131 cardiovascular events occurred. After adjustment for various covariates, including known risk markers and ambulatory BP parameters, patients with high MS of systolic BP (hazard ratio 1.81, 95% confidence interval 1.10-2.96) and those with high MS of diastolic BP (hazard ratio 1.98, 95% confidence interval 1.19-3.28) were at higher cardiovascular risk than those with normal MS. In middle-aged treated hypertensive patients, high MS of systolic and diastolic BP is independently associated with increased cardiovascular risk., (©2019 Wiley Periodicals, Inc.)
- Published
- 2019
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