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Sulfide and persulfide are chemically different and one might expect persulfide to be more effective in mediating sulfur signaling because persulfide can directly modify protein cysteine residue. However, rapid scrambling, and interconversions occur among sulfur species. Then there is the question of whether the chemical reactivity differences between sulfide and persulfide would translate into pharmacological differences. Utilizing a delivery system to generate pure hydrogen sulfide (H2S), hydrogen persulfide (H2S2), and N‐acetyl‐l‐cysteine persulfide (N‐CysSSH), we examined the activities of sulfide and persulfide in vitro and in vivo. Persulfide prodrugs exhibited increased activities compared to the H2S prodrug. In particular, the H2S2 prodrug offers much‐elevated analgesic effects compared to the H2S prodrug in vivo. Persulfide prodrugs also possess a reduced level of toxicity compared to the H2S prodrug in vivo, indicating persulfide might represent a better therapeutic paradigm than H2S. [ABSTRACT FROM AUTHOR]

Hydrogen Persulfide Prodrug, Hydrogen Sulfide Prodrug, Sulfur Chemistry, Sulfur Species Das H SB 2 sb S SB 2 sb -Prodrug weist im Vergleich zum H SB 2 sb S-Prodrug eine höhere Aktivität und geringere Toxizität in vivo auf, was darauf hindeutet, dass Persulfid ein besseres therapeutisches Agens darstellen könnte als H SB 2 sb S. B Photokatalyse b In ihrer Zuschrift (e202202079) verwenden Masaichi Saito, Stephan Kupfer, Benjamin Dietzek-Ivansi'c, Wolfgang Weigand et al. einen edelmetallfreien Photokatalysator bestehend aus einem Mimetikum der [FeFe]-Hydrogenase für die Wasserstoffentwicklung unter sichtbarem Licht. Keywords: Hydrogen Persulfide Prodrug; Hydrogen Sulfide Prodrug; Sulfur Chemistry; Sulfur Species EN Hydrogen Persulfide Prodrug Hydrogen Sulfide Prodrug Sulfur Chemistry Sulfur Species 1 1 1 05/05/22 20220509 NES 220509 B Eine Serie von Schwefel-Prodrugs b (verkapselte reaktive Schwefelspezies), die reinen Schwefelwasserstoff (H SB 2 sb S) und Persulfidwasserstoff (H SB 2 sb S SB 2 sb ) freisetzen können, wurde von Bowen Ke et al. in ihrer Zuschrift (e202201668) verwendet, um die pharmakologischen Unterschiede zwischen Sulfid und Persulfid zu untersuchen. [Extracted from the article]

Hydrogen Persulfide Prodrug, Hydrogen Sulfide Prodrug, Sulfur Chemistry, Sulfur Species Keywords: Hydrogen Persulfide Prodrug; Hydrogen Sulfide Prodrug; Sulfur Chemistry; Sulfur Species EN Hydrogen Persulfide Prodrug Hydrogen Sulfide Prodrug Sulfur Chemistry Sulfur Species 1 1 1 05/05/22 20220509 NES 220509 B A series of sulfur species prodrugs b (reactive sulfur species in a capsule) that can release pure hydrogen sulfide (H SB 2 sb S) and hydrogen persulfide (H SB 2 sb S SB 2 sb ) was used by Bowen Ke et al. in their Communication (e202201668) to compare the pharmacological differences between sulfide and persulfide. Cover Picture: Prodrugs of Persulfide and Sulfide: Is There a Pharmacological Difference between the Two in the Context of Rapid Exchanges among Various Sulfur Species In Vivo?. [Extracted from the article]