1. Indocyanine green fluorescence-guided surgery in head and neck cancer: A systematic review.
- Author
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De Ravin E, Venkatesh S, Harmsen S, Delikatny EJ, Husson MA, Lee JYK, Newman JG, and Rajasekaran K
- Subjects
- Humans, Indocyanine Green, Margins of Excision, Optical Imaging methods, Head and Neck Neoplasms diagnostic imaging, Head and Neck Neoplasms surgery, Surgery, Computer-Assisted
- Abstract
Objective: To assess the feasibility and effectiveness of indocyanine green (ICG) for image-guided resection of head and neck cancer (HNC)., Data Sources: PubMed, Embase, and Scopus databases., Review Methods: Searches were conducted from database inception to February 2022. Patient and study characteristics, imaging parameters, and imaging efficacy data were extracted from each study., Results: Nine studies met inclusion criteria, representing 103 head and neck tumors. Weighted mean ICG dose and imaging time were 1.27 mg/kg and 11.77 h, respectively. Among the five studies that provided quantitative metrics of imaging efficacy, average ICG tumor-to-background ratio (TBR) was 1.56 and weighted mean ONM-100 TBR was 3.64. Pooled sensitivity and specificity across the five studies were 91.7 % and 71.9 %, respectively., Conclusion: FGS with ICG may facilitate real-time tumor-margin delineation to improve margin clearance rates and progression-free survival. Future studies with validated, quantitative metrics of imaging success are necessary to further evaluate the prognostic benefit of these techniques., Competing Interests: Declaration of competing interest None., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
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