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Oropharyngeal cancer is characterized by high morbidity and mortality. Prognostic factors for this cancer are therefore useful to predict overall survival and may provide additional therapeutic targets.To evaluate the 5-year overall survival and prognostic factors for oropharyngeal squamous cell carcinoma.Retrospective cohort (2008-2018) of a cancer referral center. The population of the study was a hospital-based cohort consisting of patients diagnosed with oropharyngeal cancer who underwent surgery and/or adjuvant therapy (radio- and/or chemotherapy).A total of 253 patients with oropharyngeal squamous cell carcinoma were analyzed. The mean age was 59.8 ± 11.9 years and there was a male predominance (81.8%). Smoking and alcohol consumption were found in 88.0% and 84.2% of the sample, respectively. The combination of radiotherapy and chemotherapy was the treatment modality in 42.7% of the sample, followed by surgery combined with radio- and chemotherapy in 15.8%. There were 143 deaths (events), the mean survival was 11.55 ± 9.69 months, and the 5-year overall survival rate was 1.1%. Overall survival was lower for clinical stage III/IV (p 0.001), HPV p16-negative status (p = 0.019), and an interval 4 weeks between diagnosis and the beginning of treatment (p 0.007).Among the prognostic factors analyzed in this cohort, p16-negative status as a poor prognostic indicator and tumor stage III/IV and an interval longer than 4 weeks between diagnosis and the beginning of treatment were significantly associated with lower overall survival.

Background The objective of this study was to describe the upper and lower lip lesion occurrence in an oral diagnostic service. Material and Methods Retrospective descriptive sectional study was performed. Clinical records were obtained from the archives of an Oral Diagnostic Service referral center between 2006 and 2016. Data such as gender, age, anatomical location, and diagnosis were collected and categorized. The collected data were submitted to a descriptive analysis and Pearson's chi-square test (p ≤ 0.05). Results A total of 587 patient records of lip lesions were analyzed. Most lesions were diagnosed in female (52.1%) and adults (56.9%) patients in the lower lip (76.2%). Among all lip lesions, the reactive/inflammatory lesions (n = 238; 40.5%) and oral potentially malignant disorders (n = 164; 28%) were the most frequent group lesions. Mucocele (n = 147; 25%), actinic cheilitis (n = 136; 23.1%) and vascular lesions (n = 51; 8.7%) were the most frequent lesion in the sample. Actinic cheilitis was significant in relation to gender (p < 0.001), all three most frequent lesions were significant in concerning to age group and anatomical site. Conclusions Mucocele was the most common lower lip lesion in all age groups, followed by actinic cheilitis and vascular lesions, which mainly affected adults and the elderly. Key words:Lip, lip lesions, oral diseases, epidemiology.

Juvenile ossifying fibroma (JOF) is an uncommon benign fibro-osseous lesion that affects young individuals and presents an aggressive clinical behavior and high rates of recurrence. This paper aims to report 7 cases diagnosed as JOF in a reference center, correlating them with clinical-pathologic aspects in the literature. We found 7 cases diagnosed as JOF with the age of patients ranging from 11 to 39 years. The mandible was the most common location, and in 3 cases pain symptoms were reported. Regarding the histopathologic findings, the majority of cases had a well-cellular pattern, and the trabecular subtype was the most commonly found. It was observed that in 3 cases that had relapsed, 2 had conservative treatment. In view of this, it is important to know the clinical-pathologic aspects of this lesion to perform a correct diagnosis and appropriate treatment to reduce the high recurrence rate of this lesion.

Objective To develop a Clinical Index for Actinic Cheilitis (CIAC) with the intention of assisting in the identification of clinical characteristics that indicate a greater severity of this condition. Study Design CIAC was developed through the opinion of experts, being applied in 20 patients with QA and indicated for biopsy. The scores obtained after application of the index were associated with the histopathologic grading for oral epithelial dysplasia from the World Health Organization (WHO) and the Binary System using Fisher exact test (P Results There was no statistically significant association between clinical characteristics and degree of dysplasia. The cut-off point with value 11 exhibited better performance for ROC curve and higher percentage for specificity, PPV, and accuracy in both histopathologic grading analyzed. Conclusions The cut-off point 11 can be used to indicate higher degree of severity of the AC, suggesting that out of this score patients are indicated for biopsy. The size of the sample and the need to verify the reproducibility of the index make it necessary to carry out further researches.

A 43-year-old female patient attended the oral maxillofacial and traumatology service presenting volume increase in the right hemiface with painful symptomatology. At the intraoral examination, an exophytic lesion involving the alveolar ridge and palate region was observed, extending to the right nostril. The lesion showed a partially ulcerated surface, with purulent secretion, firm consistency, and normal mucosal color. Computed tomography revealed a mixed appearance of hyperdensity and ill-defined hypodensity in the maxillary region with extension to the zygoma and the right orbit. Because of poor oral hygiene and a history of regression with antibiotic therapy, a clinical diagnosis of actinomycosis was issued, and incisional biopsy of the lesion was subsequently performed. In the microscopic analysis, proliferation of pleomorphic and atypical malignant mesenchymal cells was associated with deposition of osteoid matrix, thus confirming the histopathologic diagnosis of osteosarcoma. The patient was referred to the State Reference Center for appropriate treatment.