1. A Clinico-Pathological & Radiological Co-Rrelation of Response to Anthracycline Based Neoadjuvant Chemotherapy in Locally Advance Breast Cancer (Labc) In A Teriary Care Hospital.
- Author
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Khade, Sagar K., Dasre, Dayanandsagar H., and Manza, Jawansing T.
- Subjects
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LOBULAR carcinoma , *CANCER patients , *NEOADJUVANT chemotherapy , *BREAST cancer , *METASTATIC breast cancer , *SURGERY - Abstract
Background: Breast cancer is the most prevalent malignancy diagnosed in women globally (22%), and it ranks second to cervical cancer (18.5%) in India. Breast cancer is becoming more prevalent in both developed and developing countries; the peak occurrence of breast cancer in developed countries occurs after the age of 50, whereas it occurs after the age of 40 in India. Objectives: 1. To correlate clinical, radiological, and gold standard pathological parameters in assessing the tumor response to Neoadjuvant chemotherapy (NACT) in locally advance breast cancer (LABC). 2. To find out the rates of response after neoadjuvant chemotherapy in patients of locally advanced breast cancer under following categories a. Clinical, b. Pathological, c. Radiological 3. To study the various prognostic factors to determine the outcome of the disease related to mortality and morbidity. Material & Methods: Study Design: Prospective hospital based observational study. Study area: The study was carried out in the Department of General surgery, B.J Government Medical College and Sassoon general Hospital, Pune. Study Period: 1 year. Sample size: study consisted of 55 subjects. Sampling method: Simple random Sampling Technique. Study tools and Data collection procedure: The following protocol was followed • Clinically and radiologically (by Mammography) suspected cases of locally advanced Ca breast were enrolled for the study after informed written consent. • Histopathological diagnosis was made by FNAC. • In the cases where FNAC was not conclusive, tru-cut biopsy was done • Once histopathological diagnosis was confirmed estrogen and progesterone receptor status was found out by immunohistochemistry. • Clinical stage IIIa and IIIb i.e locally advanced breast cancer (LABC) patients were considered for the further study (total number of patients was 55). Results: A total of 18 (29%) patients had clinical complete response (CCR) of these 16 patients, only 10 patients (62.5%) had a correlating pathological complete response (pCR). In our study. 53 (90- 4%) patients had an infiltrating ductal carcinoma while 2 had infiltrating lobular carcinoma. Majority (94 29%) of the patients had an infiltrating ductal carcinoma. Conclusion: The current study reveals that clinical assessment of response to NACT has higher sensitivity than radiological assessment, but the overall poor sensitivity and specificity rates of clinical assessment need the search for a better way of evaluation. [ABSTRACT FROM AUTHOR]
- Published
- 2023