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Periprosthetic femoral re-fractures (PFRFs) represent an emerging challenge for orthopaedic surgeons, since their incidence is growing in the last years, but very few experiences about their management have been currently published. The present study aims to (1) introduce, for the first time, an etiologic classification for PRFRs and (2) to provide surgical and pharmacological tips for the correct management of these injuries. Periprosthetic femoral re-fractures (PFRFs) could be classified into traumatic-PFRFs (T-PFRFs) and pathological-PFRFs (P-PFRFs). T-PFRFs, i.e. the "true" periprosthetic re-fractures, present as new fracture lines occurring proximally or distally to a previous periprosthetic fracture, that has correctly healed. They are generally unpredictable injuries but, in selected cases, it is possible to predict them by analyzing the construct used in the treatment of the previous periprosthetic fracture. P-PFRFs, on the other hand, define re-fractures occurring on a previous periprosthetic non-union or delayed union: the new fracture line appears in the same district of the old one. According to the etiologic factors influencing the P-PFRFs pathogenesis, it is possible to define re-fractures caused by mechanical failures, biological failures, septic failures and multifactorial failures, i.e., a combination of the previously mentioned concerns. A successful postoperative outcome, following the surgical management of PFRFs, requires the correct identification of all the underlying causes, which should be promptly and appropriately managed.

Background There is a need for a novel therapeutic strategy for an earlier prediction of long bone union failure as compared to previous methodologies. This study aimed to determine whether a combination of two diagnostic tools would result in a more accurate diagnosis of delayed union. Methods The inclusion criteria were as follows: patients with tibial shaft fracture who underwent treatment with intramedullary nailing (IMN) as definitive internal fixation (IF). The study included a total of 114 patients with 116 tibial shaft fractures treated with IMN as definitive IF. Radiographic apparent bone gap (RABG) and nonunion risk determination score (NURDS) can be used to predict nonunion. However, this study aimed to determine whether combination of RABG and NURDS could help deduce a more accurate prediction of delayed union. Results The union rate was found to be 85% (99 fractures), the delayed union rate was found to be 15% (17 fractures), and the rate of nonunion requiring additional surgical intervention was estimated to be 4% (5 out of the 17 delayed union cases). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of RABG were found to be 82.3%, 76.0%, 36.8%, and 96.2%, respectively, when an RABG cutoff value of 5.0 mm was applied to our patient cohort. The sensitivity, specificity, PPV, and NPV of NURDS were found to be 47.1%, 82.0%, 30.8%, and 90.1%, respectively, when a NURDS cutoff value of 8.0% was applied to our patient cohort. When RABG and NURDS were above their respective cutoff values, the sensitivity and PPV were estimated to be 90.0% and 56.3%, respectively. When RABG and NURDS were below their respective cutoff values, the specificity and NPV were estimated to be 90.1% and 98.5%, respectively. Conclusions The combination of RABG and NURDS evaluation immediately after surgery helps surgeons identify patients who are at a high risk of delayed union, facilitating careful monitoring of these patients and consideration of additional treatments.

Background Non-operative treatment with immobilization is the gold-standard for paediatric clavicular fractures. Purpose of this study is to evaluate functional outcomes and efficacy of non-operative treatment of clavicular fractures in a succession of 131 children. Methods Between 2006 and 2012, we treated non-surgically 131 children for a clavicular fracture. All fractures have been classified according to Robinson classification. Clavicle shortening, range of movements and muscular strength through the Medical Research Council (MRC) scale were evaluated. To assess the outcomes, QuickDASH questionnaire, dividing the sample in 3 age-related group, was administered. Results The average follow-up was 26 months (8-84 months). Clavicle shortening at the time of injury occurred in 18 cases. All fractures reached union. Average time to union was 34 days. Mean time return to activity was 12.6 weeks. No cases of nonunion or delayed union were reported. Complications occurred in 21 cases. A shortening persisted in 2 cases. Only one patient had a slight functional restriction. Average QuickDASH score was 6.2±1.1 (range 4.3-9.4). All patients recovered to a MRC score of 5, except for one patient with a score of 4. Best QuickDASH scores were observed in the group aged under 8 years and in non-comminuted and lateral third fractures of the clavicle. Conclusions Observing results, clavicle fractures have a satisfactory clinical healing as shown by the good scores at QuickDASH and MRC scale. Younger children under 8 years can achieve the best results with a conservative treatment in terms of bone healing and activity level.

Background: The purpose of our study was to review a series of patients with scaphoid fractures to determine whether there was an association between lunate morphology and progression to delayed union or nonunion when treated operatively or nonoperatively. Secondary aims included evaluation of the relationship between lunate morphology and scaphoid fracture location. Methods: A retrospective review of all patients with a diagnosis of scaphoid fracture was performed at our institution between 2014 and 2017. Medical records and radiographs were evaluated to determine lunate morphology, scaphoid fracture location, treatment, and time to union. Differences between groups were determined using χ2 analysis with significance set at P

Recent studies have reported that confined high-intensity and diffuse low-intensity on sagittal T2-weighted magnetic resonance imaging (MRI) are distinctive features that are highly predictive of delayed union or nonunion on osteoporotic vertebral fracture (OVF). The objective of this study was to identify the characteristics of imaging findings predicting the risk for requiring surgical treatment in fresh OVF with poor prognostic features on MRI.We conducted a retrospective study of 74 patients (17 men and 57 women with a mean age of 81.1 years) of OVF with the poor prognostic MRI findings. We compared the imaging findings between the surgery group (16 patients) and the conservative group (58 patients): vertebral instability defined as the difference between the vertebral collapse ratio in dynamic X-rays, and the grade of posterior wall injury (Grade I, no spinal canal encroachment; Grade II,2 mm; Grade III, ≥2 mm) as well as the presence or absence of pedicle fracture (Grade I, none; Grade II, unilateral; Grade III, bilateral) on computed tomography.The mean vertebral instability was 24.0% ± 10.1% in the surgery group and 13.0% ± 7.8% in the conservative group, which was significantly different. Posterior wall injury in the surgery and conservative groups was Grade I in 0 and 29 cases, Grade II in 5 and 21 cases, and Grade III in 11 and 8 cases, respectively, constituting a significant difference. Pedicle fracture in the surgery and conservative groups was Grade I in 5 and 55 cases, Grade II in 6 and 2 cases, and Grade III in 5 and 1 case, respectively, also constituting a significant difference.The most high-risk OVF patients with poor prognostic MRI findings who required surgical treatment were those who exhibited greater vertebral instability as well as either more severe posterior wall injury or pedicle fracture.Retrospective clinical study.

BACKGROUND One of the most common complications following surgery for midshaft clavicle fracture is nonunion/delayed union. Extracorporeal shock wave therapy (ESWT) is an alternative to promote new bone formation without surgical complications. To date, no literature has reported low-intensity ESWT (LI-ESWT) in delayed union of midshaft clavicle fracture. CASE SUMMARY We reported a 66-year-old Chinese amateur cyclist with clavicle delayed union treated with 10 sessions of LI-ESWT (radial, 0.057 mJ/mm2, 3 Hz, 3000 shocks). No anesthetics were applied, and no side effects occurred. At the 4 mo and 7 mo follow-ups, the patient achieved clinical and radiographical recovery, respectively. CONCLUSION In conclusion, our findings indicated that LI-ESWT could be a good option for treating midshaft clavicular delayed union.

In this peculiar setting, the infiltrations with BMA proved to be an efficient alternative tool for the treatment of severe thoracic rib trauma and delayed union. The patient returned with no complaints and CT evidence indicated that all of the fractured ribs had complete consolidation. Pain and functional outcome of the chest wall in terms of stability improved with the help of this orthobiologic alternative.

Background: The understanding of the anatomy of the proximal portion of the fifth metatarsal is essential as it explains the injury process and cures of various kinds of fifth metatarsal fractures that influence the appropriate treatment decision. Work objective: Comparison of clinical and radiographic outcomes among conservation therapy and acute surgical therapy of the fifth-metatarsal fracture base. Methods and patients: Twenty patients have been treated with percutaneous fixation with a 4,0 mm cannula screw and 20 have been conservatively treated with a lower knee cast. The length of the injury to hospital admission varied from 1 to 3 days with an average of 2 days between September 2020 and May 2021. The average follow-up time was six months (range from 5 to 7 months). Findings: Our results revealed that for zone 2 and zone 3 the acute fixation is superior than casting with respect to the union time and the AOFAS score. Conclusion: Early screw fixing is a safe and efficient therapeutic technique for acute fifth metatarsal base fractures, particularly zones 2 and 3. Early operational therapy leads to before clinical union and enables patients to return to regular daily activities rather than to cast therapy, leading to a high delayed union rate.

Introduction: Our objective was to evaluate clinical results and functional outcomes of extraarticular distal tibia fracture treated using anatomical osteosyntheses by minimally invasive percutaneous plate osteosynthesis (MIPPO) technique. Materials and Methods: 30 patients of closed distal tibial extraarticular fractures operated by MIPPO technique from November 2018 to October 2019 with age from 20 to 60 years with or without fibula fracture upto 5 cm proximal to distal tibiofibular syndesmotic joint were included in the study. Clinical and radiological assessment for fracture union were performed at 3 weeks,12 weeks and 24 weeks interval and results were analysed by using AOFAS Ankle-Hind foot scale. Results: Thirty patients were followed for 6 months with mean fracture healing time was 16 weeks (12-60 weeks). 14 patients had excellent results with AOFAS score with two patients (6.7%) had delayed union and one patient (3.3%) developed superficial infection but fractures united completely. Conclusion: Minimally invasive percutaneous plate osteosynthesis technique is an effective method of treatment for distal tibial fractures, it provides good, stable fixation with minimal complications.

Romosozumab is a humanized, anti-sclerostin monoclonal antibody used to treat osteoporosis, which increases bone formation and decreases bone resorption. It enhances fracture healing and systemic romosozumab administration may have therapeutic potentials for accelerating bone healing of even nonunion. Herein, a 61-year-old heavy smoker male with distal radius nonunion who achieved successful bone union by combination therapy of romosozumab and spanning distraction plate fixation with bone graft substitutes was presented. Through the dorsal approach, atrophic comminuted nonunion of the distal radius was sufficiently debrided. Reduction of the distal radius was performed using indirect ligamentotaxis, and a 14-hole locking plate was fixed from the third metacarpal to the radial shaft. A beta (β) tricalcium phosphate block was mainly packed into the substantial metaphyseal bone defect with additional bone graft from the resected ulnar head. Postoperatively, systemic administration of monthly romosozumab was continued for six months. Complete bone union was achieved 20 weeks postoperatively and the plate was, then, removed. Wrist extension and flexion improved to 75o and 55o, respectively, without pain, and grip strength increased 52 weeks postoperatively from 5.5 kg to 22.4 kg. During romosozumab treatment, bone formation marker levels increased rapidly and finally returned to baseline, and bone resorption marker levels remained low. In conclusion, combination of systemic romosozumab administration and grafting β-tricalcium phosphate with bridge plating provides an effective treatment option for difficult cases of comminuted distal radius nonunion with risk factors such as smoking, diabetes, and fragility.

Background Arthroscopic ankle arthrodesis (AAA) has risks of complications, such as delayed union and non-union. The number and direction of the inserted screws have been reported as important factors affecting the time to union of AAA. However, the ratio of inter-screw distance (ISD) to tibial width (TW) in different planes has not been investigated. Therefore, we aimed to explore the effect of this ratio on bone union following AAA. Methods We retrospectively enrolled 63 patients (64 ankles) undergoing AAA from 2013 to 2019. Then, their age, body mass index (BMI), sex, diabetes mellitus (DM) status, Takakura–Tanaka classification, number of screws and radiographic parameters were analysed. Results The patients had a mean age of 70.3 (range, 45–91) years. Bone fusion was achieved in 57 ankles (89%) in a mean period of 3.3 (range, 2–6) postoperative months. There were four cases of delayed union and three of non-union. No significant differences in age, BMI, sex, DM, Takakura–Tanaka classification, and number of screws could be detected between the groups. However, the sagittal ISD/TW ratio was significantly larger in the union group than in the delayed/non-union group with a cut-off value of 57.0%. Conclusion Larger sagittal ISD/TW ratios result in reduced post-AAA delayed union or non-union. The surgeon should be aware that the anterior and posterior screw widths should be approximately 60% or more of the anteroposterior width of the tibia.

Low intensity pulsed ultrasound (LIPUS) therapy has demonstrated clinical effectiveness in achieving union in a variety of fracture situations. Few studies have investigated the effectiveness of LIPUS therapy in foot and ankle surgery. The overall rate of union in all published studies relating to the use of LIPUS in a variety of foot and ankle fracture and fusion situations is 95%. Some studies suggest lower healing rates (~ 67%) when LIPUS therapy is used to treat hindfoot fusion nonunion. A well-powered, high-quality, randomized controlled trial is needed to demonstrate the clinical and cost effectiveness of LIPUS therapy in foot and ankle surgery. Cite this article: EFORT Open Rev 2021;6:217-224. DOI: 10.1302/2058-5241.6.200045

Introduction: Tibia shaft fractures are very common in children usually they are following fall. Generally they are very well treated with conservative management, but surgical intervention becomes mandatory in the presence of unstable, comminuted fractures with poor skin condition and compartment syndromes . Material and Methods: There were 6 compound comminuted tibia fractures in between age group of 5 – 15 years. All were treated with ilizarov ring fixator application in department of orthopaedics of Pravara institute of medical science (DU) from April 2019 to January 2021. Results: Early mobilization was initiated in all patients as per pain tolerance by post-operative day 2 or 3. Fracture united in all cases, no residual deformity seen in any case. Mild pintract infection was seen in 3 cases which were treated with regular dressings & oral antibiotics. No delayed union, re fracture, limb length discrepancy was seen in any case, no bone grafting, corrective osteotomy was required in any case. All cases returned to their pre injury functional status. All cases completed their one year follow up. With little initial hesitation all patients well tolerated frame. Conclusion: Ilizarov ring fixator can be considered as safe effective definitive treatment option for paediatric compound comminuted tibia fractures as its minimally invasive, biomechanically stable, dynamic, versatile treatment modality which promotes not only fracture union but also allows rapid early rehabilitation and functional recovery.

Background: Cells aspirated from bone marrow have been shown to provide stimulus for osteogenesis in animal experiments and in clinical evaluation of bone graft and bone substitutes. Despite this osteogenic characteristic, the clinical use of marrow as an osteogenic source has remained limited. The marrow is harvested by means of needle aspiration from the patient's pelvic bone and is then injected percutaneously at the nonunion site. This method offers the advantage of treating fracture-healing problems without operative exposure of either the donor or the recipient site.Aim: The purpose of this study was to ascertain the osteogenic potential of autologous bone marrow injection and its effectiveness in the management of delayed union and nonunion.Material and Methods: Autologous marrow injection was used to stimulate healing in 26 out of 34 patients were males. patients with delayed union and nonunion of fracture of the long bones This prospective study was done in Orthopaedic department of Darbhanga Medical College and Hospital in Laheriasarai, Darbhanga over a period of 2 years (2018 – 2020).Surgical Technique: Bone marrow aspirated from the iliac crest was injected at the fracture site.Results: Marrow stimulated callus formation sufficient to unite in delayed unions and nonunions immobilized with cast or intramedullary nails.Conclusion: Bone marrow injection was as effective as open autogenous grafting but with considerably less complications. Thus, the technique provides a reliable source of osteogenic stem cells with numerous advantages compared with standard open grafting techniques.

Objectives The aim of this study was to determine the rate of delayed or nonunion of fifth metatarsal fractures in skeletally immature patients. Using this information, we sought to develop an evidence-based clinical care pathway in order to mitigate unnecessary patient radiation exposure, costs to families, and costs to the health system. Methods We retrospectively reviewed the charts and radiographs of patients who presented to an academic tertiary-care paediatric hospital between 2009 and 2014 with isolated fifth metatarsal fractures. Results A total of 114 patients (61 males and 53 females) with mean age of 11.2 (SD 3.0) years old were included in the study. No patients required operative management. There was one case of delayed union and no cases of nonunion. There was no association of these complications with fracture type, location, or mechanism of injury. There was no association of complications with immobilization type or immobilization period. Despite the low complication rate and need for surgery, fracture clinic resource utilization was significant. Fractures were managed with a mean number of 3.1 (SD 0.89) clinic visits and a mean number of 2.7 (SD1.0) radiology department visits where a mean total of 7.9 (SD 3.4) x-rays were performed. Conclusions Based on our retrospective review, skeletally immature patients presenting with isolated fifth metatarsal fractures have a very low rate of delayed or nonunion. A selective follow-up strategy will decrease radiation exposure, reduce costs to families and the healthcare system, without compromising clinical outcomes.

Introduction: Long bone fractures are among the most common orthopaedic injuries encountered. A fracture that fails to progress to union despite appropriate fixation and absence of complications presents a treatment dilemma to the surgeon. The usual solution of re-fixation with or without bone graft constitutes repeat exposure to surgery and its risks, as well as added morbidity and cost. Recent advances in molecular biology suggest Platelet rich plasma (PRP) may have bone forming potential. This study was done to determine whether PRP has any beneficial role in patients with delayed healing of long bone fractures. Methods: A prospective interventional study was done on patients arriving at the department of orthopaedic surgery of Kathmandu Medical College with delayed union of long bone fractures after internal fixation between January 2014 and January 2017. Patients were treated with local injection of group-matched PRP directly into the fracture gap and were followed-up for six months to check for radiological signs of fracture union. Results: A total of 10 fractures were included in 10 patients that involved four humeri, three tibiae, and three femora. Eight out of the 10 fractures united at a median time of three months after the injection. Two had non-union that required revision surgery. Conclusion: Local Platelet rich plasma injection may constitute a ‘nothing to lose, everything to gain’ intermediate option before a decision for major reoperation on such patients is made.

The aim was to evaluate the results of platelet rich plasma (PRP) infusion in postponed joined tibial cracks. Development factors have a part in angiogenesis and osteogenesis by upgrade of separation of undifferentiated mesenchymal cells. Platelets are wealthy in these development factors. The point of use of PRP in crack site to upgrade osteogenesis. Sixteen patients with postponed joined tibial shaft cracks were overseen by PRP infusion and surveyed from April 2018 till April 2019 at Banha University Hospital. Postoperative appraisal was done clinically and radiologically by radiological association size of tibia (RUST). Last evaluation was done at a half year postoperatively and the outcomes were as per the following: Complete crack recuperating was acquired in 14 patients (87.5%) with mean time 3.07 ± 0.92 with range 2 - a half year, and just two patients (12.5%) didn't show any association after development for a half year and was named as disappointment of treatment. No complexities identified with careful procedure were noticed. A few patients created subcutaneous expanding of not many centimeters in width at the infusion site. Platelet-rich plasma is a protected and powerful treatment of deferred association tibial shaft fractures.

Navicular stress fractures are multifactorial injuries due to chronic overload on the navicular, particularly in young athletes. The navicular is subject to unique stresses and has a complex blood supply, making it susceptible to stress fractures and potentially delayed union or nonunion. Expeditious diagnosis is critical to prevent a delay in treatment and a poor outcome. Advanced imaging is essential in making the diagnosis and monitoring healing. Both nonsurgical and surgical treatments have demonstrated good results. Nonsurgical management consists of a period of immobilization and nonweight bearing, and surgical management typically involves open reduction and internal fixation. Patients need to be appropriately counseled regarding expectations for these challenging injuries.

Extracorporeal shock wave therapy (ESWT) has been demonstrated to accelerate bone healing; however, the mechanism underlying ESWT-induced bone regeneration has not been fully elucidated. This study aimed to examine the effects of ESWT and the process of fracture healing. A rat model of femur delayed-union was established by cauterizing the periosteum. ESWT treatment at the fracture site was performed 2 weeks after the operation and the site was radiographically and histologically evaluated at weeks 4, 6, and 8. The bone union rate and radiographic score of the ESWT group were significantly higher than those of the control group at 8 weeks. Histological evaluation revealed enhanced endochondral ossification at the fracture site. The effects of ESWT on ATDC5 cells were examined in vitro. ESWT promoted chondrogenic differentiation without inhibiting the proliferation of ATDC5 cells. ESWT may induce significant bone healing by promoting endochondral ossification at the fracture site.

Introduction The most feared and challenging complication in treating patients with musculoskeletal trauma is infection after fracture fixation, which can delay healing and, in turn, result in permanent functional loss of limbs or even amputation. Case presentation Here, we describe a case in which a patient presented with stage 4 chronic osteomyelitis on the right tibia and fibula. To treat the late infection by eradicating or reducing the infection, it was recommended to replace the internal fixation with surgical debridement for 6 weeks and antibiotics for 6–12 weeks until the internal fixation device could be removed. Conclusion Delayed union and chronic osteomyelitis are possible complications of IAFF., Highlights • Infection after fracture fixation is the most feared and challenging complication in treating patients with musculoskeletal trauma. • We report the rare case of a male suffering stage 4 chronic osteomyelitis due to Staphylococcus epidermidis. • Disruption of fracture healing is a clinical symptom that often arises in late infections caused by microorganisms such as Staphylococcus epidermidis.

Introduction: Human hand has evolved into an organ of exceptional function which is capable of complex movements & manipulation. Varieties of functions vary widely from pinch grip, hook function to powerful grip for lifting heavy weights. 15% of hand injuries are of Metacarpals and phalanges. Phalangeal fractures either closed or open are the most common injuries of the hand. These injuries can be treated conservatively or operatively depending on nature of injuries, fracture pattern & fracture stability. Principle management involves restoration of articular congruity, fixation of Fractures with external fixation devices. Materials and Methods: We did a prospective, non randomized study for a duration 6 months for a patient population of 17 who had phalangeal & metacarpal fractures. After ethical clearance & consent they were included in the study. Fractures were stabilized by threaded k wires, link joints and connecting rods. Reduction was achieved under c-arm guidance. Patient were followed up periodically for pin tract infection, loosening of k wires & link joint loosening. Excellent results were achieved in majority of patients and with few patients in average & poor results. Results: Out of 17 patients 10 were males & 7 were females, most of the injuries are due to agricultural accidents, 76% of patients had good union with 24% had delayed union,65% were open fractures & 35% closed injuries, 11 were extra- articular & 6 were intra-articular fractures, The majority fractures were of proximal phalanx followed by metacarpals, 47% patients had excellent outcomes, 29% with good results, 18% average results & 6% poor results these were due to the pin tract infection, loosening, collapse of fracture, angulation & side to side translation.Conclusion: Our study showed that extra-articular fractures gave a better results, whereas intra- articular fractures gave average results due to stiffness of joints. And at the same time external fixator gave a better outcome.

Background: We performed a systematic review on the management of patellar fracture nonunion and report a novel suturebased non-metallic fixation technique associated with platelet-rich plasma and mesenchymal stem cell injections in the management of this injury.\ud \ud Methods: A systematic search was performed up to August 2020 in PubMed and Scopus electronic databases of scholarly articles evaluating different surgical techniques used for nonunion of patellar fractures, with no restrictions on language or year of publication. Furthermore, we describe our novel non-metallic suture fixation technique and a patient in whom this technique was applied.\ud \ud Results: A total of 9 articles were included in the systematic review. Tension band wiring was the most commonly used procedure (62.7%). Nonoperative procedures (8.1%) resulted in nonunion in all patients. The most common complication after open reduction and internal fixation was infection (7.8%). Our patient at the latest follow-up reported full functional recovery and full extension and flexion of the affected knee with no pain and subjectively normal strength.\ud \ud Conclusions: The management of patella nonunions is still a challenge. The technique reported here can be used in patellar fracture nonunion, as well as in primary patellar fractures.

Elastic intramedullary nailing is the main treatment method in the surgical treatment of pediatric forearm fractures. In this study, we compared the clinical outcomes of intramedullary nailing of forearm fractures with leaving the tips exposed and with placing the tip of the nails under the skin. We aimed to present the clinical outcomes of intramedullary nailing and determine the advantages and disadvantages of leaving the tips of the nails exposed. One hundred and ninety-two children with both-bone forearm fracture who were treated with titanium elastic nailing (TEN) in the Department of Orthopedics at Erzurum Regional Training and Research Hospital between January 2009 and December 2016 were included in the study. All cases had been followed up for at least 1 year. The tips of the TENs were left exposed in 74 and buried subcutaneously in 118 children. Union was achieved in all cases. Delayed union was observed in just one case. Skin irritation was observed in 11 (5.7%) of the exposed TEN cases. Superficial infection developed in two (1%) cases with exposed TEN tips. Migration developed during the follow-up of 11 (5.7%) cases with buried tips. The mean time to removal of TEN was 7.9 weeks in cases with exposed and 26.2 weeks in cases with buried cases. Refracture was observed in six buried (3.1%) cases and four exposed TEN (2.1%) cases in the first year after the removal of the nails. Perfect outcomes were achieved in 146 (76%) cases and good outcomes in 36 (19%) cases in our study. On comparing the rate of complications and clinicaloutcomes, leaving the TEN exposed seems to be safe.

Background: Bisphosphonate abuse is associated with atypical femur fractures, which despite different fixation methods have increased non-union, delayed union, and re-operation rates. Therefore, there is a need for a surgical technique that may enhance union in such cases. Herein we are introducing a novel technique of sequential multiple vigorous reaming across the fracture site to introduce reaming debris/endosteal bone graft around the fracture site. Materials and Methods: We present a retrospective analysis of five prospectively treated patients with atypical diaphyseal femur fracture who presented to us from January 2015 to August 2019. All the patients were followed up at regular intervals and assessed both clinically and radiologically. Results: All 5 cases operated with our technique showed union at a mean follow-up of 16 weeks (12 - 20 weeks). There were no complications reported in our study at the last mean follow-up of 25 months (12 - 51 months). Conclusion: This technique of multiple vigorous reaming at and around the fracture site provides a new paradigm in the management of AFF. The autograft around the outer cortex promotes the formation of bridging callus and results in the early union.

Highlights • A case of delayed union of type IIIa fragility fracture of the pelvis. • Evaluating the progress of bone fusion may be difficult using front and side X-rays. • This may be because of the implant position and pelvis shape. • CT enables diagnosis of delayed union and non-union in type IIIa pelvis fracture., INTRODUCTION There are no universally accepted treatment strategies for fragility fractures of the pelvis (FFPs). The incidence of delayed union or non-union of Type IIIa FFP is still unknown. PRESENTATION OF CASE We describe a case of delayed union of a Type IIIa FFP. A 96-year-old female patient who lives independently accidentally fell when exiting a car. The diagnosis of Type IIIa FFP with displaced left ilium and left pubic rami fracture. Surgical repair was performed using an anterior intrapelvic approach with constructs made using two reconstruction contoured plates to bridge the medial edge and middle part of the fracture. This case was revealed delayed union. The periodic CT examinations were performed to determine the progress of bone union. The patient returned to most social activities including living independently and the Modified Majeed score was 94 at 12 months post-operation. DISCUSSION For the case of TypeⅢa FFP, soft tissue is spread over a wide area. When the fracture site of ilium was exposed, the cortical bone was found to be thin with poor blood flow. There is a possibility that the blood flow was hindered by subperiosteal elevation of the iliacus muscle from the internal iliac fossa in this case. CONCLUSION Non-union of the iliac wings is relatively rare following high-energy pelvic ring fractures. The incidence of delayed union or non-union of Type IIIa FFP remains unknown; therefore, careful follow-up of patients who undergo treatment is necessary to reduce the risk of delayed union.

Background The outcome of non-surgical treatment is generally good, but the treatment course can be long and painful with approximately a quarter of the patients acquiring a nonunion. Both surgical and non-surgical treatment can have disabling consequences such as nerve injury, infection, and nonunion. The purpose of the study is to compare patient-reported outcomes after surgical and non-surgical treatment for humeral shaft fractures. Methods A pragmatic randomized controlled trial (RCT) is planned with two study groups (SHAFT-Young and SHAFT-Elderly). A total of 287 eligible acute humeral shaft fractures are scheduled to be recruited and randomly allocated to surgical or non-surgical treatment with the option of early crossover due to delayed union. The surgical method within the allocation is decided by the surgeon. The primary outcome is the Disability of Arm, Shoulder, and Hand (DASH) score at 52 weeks, and is assessor blinded. The secondary outcomes are DASH score, EQ-5D-5L, pain assessed by visual analog score, Constant-Murley score including elbow range of motion, and anchor questions collected at all timepoints throughout the trial. All complications will be reported including; infection, nerve or vascular injury, surgical revisions (implant malpositioning, hardware failure, aseptic loosening, and peri-implant fracture), major adverse cardiovascular events, and mortality. Discussion The SHAFT trial is a pragmatic multicenter RCT, that will compare the effectiveness of the main strategies in humeral shaft fracture treatment. This will include a variety of fracture morphologies, while taking the dilemmas within the population into account by splitting the population by age and providing the orthopedic society with an interval for early crossover surgery. Trial registration Clinicaltrials.govNCT04574336. Registered on 5 October 2020.

Introduction: This study assessed clinical outcomes and complications in patients with humeral diaphyseal fractures treated using MIPO by means of plating. Patients and Methods: 30 patients were treated with MIPO. Assessment of patients is done on the basis of union time, complication rate, blood loss, range of movement and activity by means of UCLA and MAYO Scores. Results: Primary union was achieved in all patients. Mean time to union was 11.73 ± 3. Mean operation time is 60 min. We had 3 patients with complication which includes superficial infection in 1 patient which get resolved after culture specific antibiotics, Shoulder stiffness in 1 patient and delayed union in 1 patient which got united in 29 weeks. Functional outcome was good as per UCLA and MAYO Scores. Conclusion: The MIPO technique achieves good results and less time for union in simple and complex fractures of humeral shafts. Although MIPO potentially has a radiation hazard, there is less blood loss and it reduces peri-operative complications with shortened operation time and minimal soft tissue dissection. Keywords: MIPPO, Diaphyseal Humerus Fracture, Anterior Bridge Plate

Aims The incidence of atypical femoral fractures (AFFs) continues to increase. However, there are currently few long-term studies on the complications of AFFs and factors affecting them. Therefore, we attempted to investigate the outcomes, complications, and risk factors for complication through mid-term follow-up of more than three years. Methods From January 2003 to January 2016, 305 patients who underwent surgery for AFFs at six hospitals were enrolled. After exclusion, a total of 147 patients were included with a mean age of 71.6 years (48 to 89) and 146 of whom were female. We retrospectively evaluated medical records, and reviewed radiographs to investigate the fracture site, femur bowing angle, presence of delayed union or nonunion, contralateral AFFs, and peri-implant fracture. A statistical analysis was performed to identify the significance of associated factors. Results The mean follow-up period was 70.2 months (36 to 191). There were 146 AFFs (99.3%) in female patients and the mean age was 71.6 years (48 to 89). The AFFs were located in the subtrochanter and shaft in 52 cases (35.4%) and 95 (64.6%), respectively. The preoperative mean anterior/lateral femoral bowing angles were 10.5° (SD 5.7°)/6.1° (SD 6.2°). The postoperative mean anterior/lateral bowing values were changed by 8.7° (SD 5.4°)/4.6° (SD 5.9°). Bisphosphonates had been used contemporarily in 115 AFFs (78.2%) for a mean of 52.4 months (1 to 204; SD 45.5) preoperatively. Nailing was performed in 133 AFFs (90.5%), and union was obtained at a mean of 23.6 weeks (7 to 85). Delayed union occurred in 41 (27.9%), and nonunion occurred in 13 (8.8%). Contralateral AFF occurred in 79 patients (53.7%), and the use of a bisphosphonate significantly influenced the occurrence of contralateral AFFs (p = 0.019). Peri-implant fractures occurred in a total of 13 patients (8.8%), and a significant increase was observed in cases with plating (p = 0.021) and high grade of postoperative anterolateral bowing (p = 0.044). Conclusion The use of a bisphosphonate was found to be a risk factor for contralateral AFF, and high-grade postoperative anterolateral bowing and plate fixation significantly increased the occurrence of peri-implant fractures. Long-term follow-up studies on the bilaterality of AFFs and peri-implant fractures are warranted. Cite this article: Bone Joint J 2021;103-B(11):1648–1655.

Introduction Proximal humeral fractures complicated with metaphyseal and diaphyseal extension are usually treated operatively with 3.5 mm long anatomic proximal humerus plates. However, frequently these comminuted and segmental fracture types may be associated with delayed union, nonunion, and/or plate failure. We present a technique for addressing this fracture pattern by using an anatomic contralateral 4.5 mm distal femoral plate in a reversed fashion. Methods Eleven patients (eight women and three men) with a mean age of 70 years (range, 52 to 84 years) were operated on with the described technique. The dominant hand was involved in seven out of 11 patients. There were seven acute metadiaphyseal fractures and four nonunions. In one patient, humeral shaft nonunion was associated with segmental metadiaphyseal defect and a free fibular graft was applied. Results All fractures healed and patients regained almost normal function of the affected shoulder and upper limb. Shoulder abduction and forward elevation ranged from 80 to 110 degrees (mean, 97 degrees) and 90 to 120 degrees (mean, 102 degrees), respectively. The disabilities of the arm, shoulder and hand (DASH) score varied from 6 to 11 points (median 8). No major trauma or systemic complications were recorded. Conclusion The morphology, strength, and characteristics of the plate could effectively conform to the anatomy of the proximal humerus and offer adequate stability for fracture union. The described technique is more useful in case of osteoporosis and/or presence of previous failed internal fixation that further compromise the vascularization and the mechanical properties of the bone.

The incidence of nonunion of fractures has been steadily rising owing to improved life expectancy following severe injuries along with rising cases of polytrauma. Once a nonunion is established, the chances of spontaneous healing are deemed to be quite low. Fracture nonunion continues to be a challenge in clinical practice with nonunions having a considerable impact on patient’s quality of life causing both functional and psychosocial disability. Low-Intensity Pulsed Ultrasound (LIPUS) therapy is being projected as a viable and non-interventional alternative to surgical management of nonunions and delayed unions. LIPUS therapy is being widely recommended as a standalone treatment option for the treatment of established nonunions and delayed unions as it is believed to promote healing in all phases of fracture healing viz., inflammatory, intramembranous ossification, chondrogenesis, endochondral ossification and remodelling. In the current scenario of varying results and unclear clinical role of LIPUS therapy, we present a prospective case series of fracture nonunions and delayed unions treated with LIPUS therapy at a large District General Hospital.

Background The clinical outcomes of balloon kyphoplasty (BKP) for split-type osteoporotic vertebral fractures (OVF) are poor. These may be owing to the vertebral body bifurcating anteriorly and posteriorly when a load is applied and the filled cement being unstable. We report the usefulness of BKP combined with pediculoplasty using cannulated screws (vertebra-pediculoplasty) for OVF with a risk of cement dislodgement. Methods Between April 2020 and February 2021, this surgery was performed on 10 patients with split-type and delayed-union OVF. The diagnosis was made using imaging findings on preoperative computed tomography or intraoperative images during balloon inflation. Early postoperative ambulatory rehabilitation was performed, and clinical outcomes were evaluated. Results Early pain relief was obtained in all patients. The stability of the fractured vertebrae was demonstrated using both supine and seated radiographs from the early postoperative period, and good clinical results were obtained. The cement in this surgery was stabilized using a cannulated screw in the vertebral body, anteroposteriorly, and craniocaudally. The cement mass integrated with the cannulated screw was stabilized with the vertebral lamina and pedicle as a stopper. Conclusions Vertebra-pediculoplasty could be an effective method for managing OVF with a high risk of cement dislodgement, which has been difficult to treat using conventional BKP.

Case We describe the case of a 38-year-old woman, a yoga instructor, who had pain in the right shoulder and scapular region of 4 months' duration while performing yoga. Radiography and computed tomography diagnosed delayed union of a first rib stress fracture. The delayed union of stress fracture of the first rib was successfully treated with the limiting of yoga activity and low-intensity pulsed ultrasound (LIPUS). Conclusions Physicians should be aware that even yoga posing can cause stress fractures of the first rib. LIPUS therapy may be effective for delayed union in addition to rest.

Background: Platelet-rich plasma (PRP) has been suggested as an emerging treatment for bone defects. However, whether PRP could enhance the therapeutic efficacy of autologous bone grafting for long bone delayed union or non-union remains unknown. A meta-analysis of randomized and non-randomized controlled trials (RCT and NRCT) was performed to summarize current evidence.Methods: Relevant RCTs and NRCTs comparing the influences of autologous bone grafting on healing of long bone delayed union or non-union with and without PRP were obtained by searching PubMed, Embase, Cochrane's Library, China National Knowledge Infrastructure, and WanFang databases from inception to September 10, 2020. A random-effect model was applied to pool the results with the incorporation of the potential heterogeneity. Subgroup analysis according to study design was also performed.Results: Six RCTs and two NRCTs with 420 patients were included. Compared to patients allocated to autologous bone grafting alone, those allocated to combined treatment with PRP and autologous bone grafting were not associated with higher rates of radiographic bone healing [risk ratio (RR): 1.06, 95% confidence interval (CI): 0.99–1.13, P = 0.09; I2 = 24%] or excellent/good posttreatment limb function (RR: 1.14, 95% CI: 0.95–1.37, P = 0.37; I2 = 0%) but was associated with a shorter healing time (mean difference: −1.35 months, 95% CI: −1.86 to −0.84, P < 0.001; I2 = 58%). Subgroup analysis according to study design showed similar results for the above outcomes (P-values for subgroup difference all >0.10).Conclusions: Combined treatment with PRP and autologous bone grafting may be effective to accelerate the healing of long bone delayed union or non-union compared to autologous bone grafting alone.

We report the case of a 36-year-old man, who presented to us five months after the initial trauma. He had been treated elsewhere with a cephalomedullary femoral nail. He described severe pain in his right thigh and groin that confined him to a wheelchair. He had shortening of the right lower limb and painful restriction of movements of the right hip. Radiographs demonstrated hypertrophic callus with a gap at the femoral shaft while the neck fracture was in varus malalignment with bone resorption; the neck fracture been fixed using two hip screws that were missing the nail. The patient was managed with removal of the previous hardware, reamed retrograde nailing and Pauwels' intertrochanteric valgus osteotomy fixed using a 120o double-angled condylar blade plate. Both the fracture sites were not opened. Postoperatively, the femoral shaft showed radiographic evidence of union at three months, while the femoral neck and the intertrochanteric osteotomy site had united at five months. As per the Friedman and Wyman criteria, our patient has a "good" outcome at the four-year follow-up.

The objective of this work is to present a functional evaluation of patients treated with open reduction and internal fixation of capitellum fractures using anterolateral approach. We studied the outcome of 20 consecutive patients with capitellum fractures, with one year of follow-up. Mean age in our study was 44 (range 25-60) years. 60% of patients were females in our study and non-dominant side was involved in 70% of patients. All the patients reported normal elbow function prior to trauma. RTA was the cause of injury in majority of patients and non-dominant side was injured in majority of patients. The patients were evaluated with Mayo Elbow Performance Index. All the fractures united at an average duration of 18 weeks. Mean Mayo score was 93. Mean pronation and supination were 83 and 85 degrees respectively. There were two cases of superficial infection, however got resolved uneventfully. One case of delayed union, one case of implant failure (needed revision surgery) and four cases of stiffness. We conclude that open reduction and internal fixation of coronal shear fractures of capitellum using headless screw compression via the antero-lateral approach is a reliable treatment modality and results in stable fixation with restoration of a functional arc of motion.

Introduction We retrospectively observed the fibular regeneration in non vascularized harvest in children and development of ankle valgus at 2 time points to find any possible relationship between them. Material and methods A 6 month period was chosen as the first time frame to assess regeneration and ankle valgus. Radiographs at this time and a subsequent follow up were studied for regeneration, lateral distal tibial ankle (LDTA) and fibular station. The donor sites were divided into complete and incomplete regeneration groups and compared statistically. Results There were 12 patients with 18 harvested fibulae. Ten out of 18 fibulae (56%) had complete longitudinal regenerate at 6 months. Two fibulae underwent delayed union. Of 8 incomplete regenerates at 6 months, 6 (75%) were also incomplete beyond a follow up of 2.75 years. Incomplete group had radiological ankle valgus in 6 legs (75%) at 6 months increased to 7 at follow up. Further, LDTA for incomplete group was significantly lower than complete group (p = 0.025) at 6 months. Conclusions More than half of harvested legs (56%) had complete longitudinal fibular regeneration at 6 months. Of incomplete regenerates at 6 months, three fourth remained so beyond 2.5 years. Ankle valgus was found strongly related to long standing fibular non regeneration. Radiological ankle valgus developed early in the incomplete regenerate group.

Die Auswirkung der physikalischen Stimulation eines Frakturbereichs ist aufgrund der Komplexitat der Materie bis heute nicht endgultig geklart. Unterschiede in Lokalisation, morphologischen Merkmalen der Fraktur, Weichteilschaden, Vorbehandlung (konservativ/chirurgisch) und Risikofaktoren beeinflussen die Studienergebnisse der physikalischen Modulation direkt im Sinne einer Inkonsistenz. Im Rahmen der vorliegenden Arbeit wird die Evidenz der extrakorporalen Stoswellentherapie (ESWT) und der niedrigenergetischen gepulsten Ultraschalltherapie (NEGU) dargestellt, die beide die Knochenbruchheilung beeinflussen. Die Studienlage zur Wirksamkeitsbewertung der EWST besteht aus einer einzigen randomisierten kontrollierten Studie (RCT) mit mittlerem Bias-Risiko; hier wurde ein positiver Effekt auf die knocherne Konsolidierung in 70–71 % der Falle nachgewiesen. Eine einzelne RCT impliziert fur die NEGU eine Reduktion der Ausheilungszeit frischer Frakturen, v. a. bei solchen mit zu erwartender langerer Heilungszeit. Fur die additive Behandlung von „delayed union fractures“ ergab eine hochwertige RCT eine statistisch signifikante Verbesserung des Heilungsprozess am Tibiaschaft. Eine Arbeit (systematischer Review und Metaanalyse) wies fur „nonunion fractures“ positive Effekte der NEGU nach.

Subchondral bone remodelling is an integral part of osteoarthritis and involves the development of subchondral sclerosis seen on plain imaging, along with osteophyte formation. The development of these changes is due to persistent abnormal mechanical stresses which create a cellular and biomolecular response to microfractures in the subchondral bone and osteochondral junction. An early sign is bone marrow lesions seen on MRI scanning. Healing can occur at this stage by correcting the abnormal loads. Persistence leads to what is thought to be a delayed union or nonunion response by the bone. Microfractures of the osteochondral junction, coupled with articular cartilage fissuring and loss, allows synovial fluid to penetrate the subchondral bone along with cytokines and other molecules reacting with the bone cells to increase the pathological effects. This review gives an overview of the current thoughts on subchondral bone remodelling in osteoarthritis that is aimed at orthopaedic surgeons to help in the understanding of the pathogenesis of osteoarthritis and the role of surgical management. Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180102