1. Restrictive Lung Function Is Related to Sympathetic Hyperactivity in Patients With Heart Failure.
- Author
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Joho S, Ushijima R, Akabane T, Hirai T, and Inoue H
- Subjects
- Aged, Analysis of Variance, Cohort Studies, Comorbidity, Female, Forced Expiratory Volume, Glomerular Filtration Rate, Humans, Lung innervation, Lung Diseases physiopathology, Male, Middle Aged, Multivariate Analysis, Prospective Studies, Reference Values, Spirometry methods, Vital Capacity physiology, Heart Failure epidemiology, Heart Failure physiopathology, Lung Diseases epidemiology, Stroke Volume physiology, Sympathetic Nervous System physiopathology, Vascular Resistance physiology
- Abstract
Background: Sympathoexcitation and impaired lung function are common in patients with severe heart failure (HF). However, the association between impaired lung function and sympathoexcitation remains unknown., Methods and Results: Muscle sympathetic nerve activity (MSNA) and clinical variables were determined in 83 HF patients with left ventricular ejection fraction (LVEF) <0.45. Restrictive and obstructive changes on spirometry were defined as reduced forced vital capacity (FVC) of <80% of predicted and a ratio of forced expiratory volume in the first second to FVC of <70%, respectively. Restrictive and obstructive changes were identified in 17 and 21 patients, respectively. MSNA was higher in patients with restrictive changes than in those without restrictive changes (84 vs 66 bursts per 100 beats; P < .01), but was similar in those with and without obstructive changes. Univariate analyses showed that FVC, estimated glomerular filtration rate (eGFR), specific activity scale, B-type natriuretic peptide level, LVEF, age, and use of aldosterone receptor blockers were significant predictors of MSNA burst incidence. Multivariate analysis revealed that FVC, LVEF, and eGFR were independent factors for increased burst incidence. Changes in FVC during follow-up negatively correlated with changes in burst rate (n = 11; P < .01)., Conclusion: Restrictive lung function was associated with increased sympathetic nerve activity independently from HF severity., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2017
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