1. Computerized Assessment of Wheezing in Children With Respiratory Syncytial Virus Bronchiolitis Before and After Hypertonic Saline Nebulization.
- Author
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Faber TE, Kamps AW, Sjoerdsma MH, Vermeulen S, Veeger NJ, and Bont LJ
- Subjects
- Acoustics, Auscultation instrumentation, Bronchiolitis, Viral physiopathology, Child, Preschool, Diagnosis, Computer-Assisted, Female, Humans, Infant, Infant, Newborn, Male, Nebulizers and Vaporizers, Respiration, Respiratory Sounds drug effects, Respiratory Syncytial Virus Infections physiopathology, Respiratory Syncytial Virus, Human, Saline Solution, Hypertonic administration & dosage, Severity of Illness Index, Auscultation methods, Bronchiolitis, Viral complications, Respiratory Sounds diagnosis, Respiratory Syncytial Virus Infections complications, Symptom Assessment methods
- Abstract
Background: Studies suggest an effect of nebulized hypertonic saline solution on air-flow limitation in subjects with respiratory syncytial virus (RSV) bronchiolitis, but results are based on subjective scores of clinical severity and are not clear. In this observational study, we used a noninvasive computerized tool to quantify wheezing before and after nebulization with hypertonic saline in children admitted for RSV infection., Methods: Twenty-seven children (≤ 24 months old) admitted to the pediatric ward of the Medical Center Leeuwarden with polymerase chain reaction-confirmed RSV bronchiolitis were included. Subjects were simultaneously assessed both clinically and by computerized acoustic monitoring before and 15 min after treatment with nebulized hypertonic saline solution., Results: Clinical assessment, defined by the Respiratory Distress Assessment Instrument score, did not change after nebulization (n = 27, 5.0 vs 4.7, P = .17). Computerized acoustic monitoring showed no improvement in wheezing (n = 27, 3.4% vs 2.0%, P = .05) or inspiration/expiration ratio (0.85 vs 0.85, P = .93) after nebulization., Conclusions: Hypertonic saline nebulization does not improve air flow, as assessed by both clinical and computerized acoustic scores, in children admitted for RSV., (Copyright © 2015 by Daedalus Enterprises.)
- Published
- 2015
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