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The article presents a case study of a 68-year-old woman who developed atropine-induced allergic periocular dermatitis, confirmed through patch testing after treatment for uveitis. It highlights the symptoms of pruritus, erythema, and edema around the eyes, emphasizing the significance of identifying and eliminating the causative agent to prevent further complications.

The place of pemphigus vulgaris (PV) among autoimmune bullous diseases (AIBD) is well established. It is an acquired chronic, autoimmune, vesiculobullous disease in which IgG antibodies target desmosomal proteins to produce intraepithelial mucocutaneous blistering. The diagnosis is often challenging for the clinicians. It requires a combination of three major features: clinical, histopathological, and immunological. Clinically, oral lesions are the first manifestations of the disease in 50-90% of the patients with widespread blisters affecting the oral mucosa. On the skin, lesions are characterized by flaccid blisters that rapidly progress into erosions and crust formation. Umbilical lesions as a clinical manifestation of PV are peculiar and have rarely been reported, and they are not yet completely elucidated. Umbilical region involvement in patients with pemphigus was assessed in a limited study totalling just 10 patients. This localisation may be a valuable hint easing the diagnosis at the clinical level for patients with oral mucosal blisters. Dentists must be familiar with the clinical manifestations of PV to make an early diagnosis and start an early treatment which determines the prognosis of the disease. To the best of the authors' knowledge, the coexistence of these lesions with the oral lesions as a first sign of PV in the absence of skin involvement was reported in only one case of pemphigus vegetans (PVe). In this paper, we describe an observation of a female patient that was diagnosed with PV that begun with simultaneous oral and umbilical locations which coexisted for a period of 4 months before the appearance of other cutaneous lesions. We highlight the role of dentists, by being familiar with the clinical manifestations of PV, to make an early diagnosis to start an early treatment which determines the prognosis of the disease and to follow closely the evolution of lesions to change treatment if required. We also discuss the clinical, histological, and immunological features of the disease that enabled the differential diagnosis as well as the appropriate therapeutic management. [ABSTRACT FROM AUTHOR]

Breast cancer is the first cancer associated with cutaneous metastasis (CM). The clinical presentation of these metastases is comprehensive. We report an original case of carcinoma en cuirasse associated with zosteriform metastasis that indicates the development of contralateral breast cancer. [ABSTRACT FROM AUTHOR]

Shortly, her purpuric lesions became generalized and progressed to multiple necrotic lesions (Figure 1). The differential diagnosis of these lesions in pediatric patients includes purpura fulminans, thromboembolic disease, polyarteritis nodosa, antineutrophil cytoplasmic antibodies-associated vasculitis, Stevens-Johnson syndrome, viral infections such as varicella, and pityriasis lichenoides et varioliformis acuta.1-3 IgAV is the most common type of vasculitis during childhood, occurring mainly under the age of 10 years.4 Classification criteria of pediatric IgAV were published in 2010 by the European League Against Rheumatism/Paediatric Rheumatology International Trials Organization/ Paediatric Rheumatology European Society.5 They include palpable purpura (mandatory) and at least one of the following: leukocytoclastic vasculitis with predominant IgA deposits on skin biopsy, diffuse abdominal pain, acute arthritis or arthralgia, or renal involvement (proteinuria and/or hematuria).5 Our patient, despite ulcerative and necrotic lesions as major cutaneous manifestations, met the diagnostic criteria for IgAV. Diagnosis: IgA vasculitis (Henoch-Schönlein purpura) A skin biopsy from a purpuric lesion revealed leukocytoclastic vasculitis (Figures 3 and 4). [Extracted from the article]

Pityriasis rosea is a common, acute, self limiting inflammatory skin disease. Pityriasis rosea‐like eruptions (PR‐LE) have been reported after drugs. The clinical presentation of PR‐LE can be distinguished from pityriasis rosea. We reporte a 41‐year‐old woman who developed PR‐LE 5 days after administration domperidone. The clinical presentation of Pityriasis rosea‐like eruptions (PR‐LE) can be distinguished from pityriasis rosea. Herald patch and prodromal systemic symptoms are absent in PR‐LE, and lesions are more confluent forming large itchy lesions. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 58-year-old male with type 2 diabetes. Topics include manifesting as tumid violaceous plaques with keratin‑filled mila‑like cysts and comedones commonly affecting the retroauricular area; and lesions exhibiting perifollicular pigmentation, follicular plugs, multiple rosettes, and Wickham striae.