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Your search keyword '"van der Graaf, P H"' showing total 6 results
Start Over Author "van der Graaf, P H" Topic systems biology
6 results on '"van der Graaf, P H"'

1. Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation.

Author

Ribba B, Grimm HP, Agoram B, Davies MR, Gadkar K, Niederer S, van Riel N, Timmis J, and van der Graaf PH

Subjects
Congresses as Topic, Drug Design, Drug Discovery methods, Humans, Systems Biology methods
Abstract

With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions., (© 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.)

Published
2017
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2. A Six-Stage Workflow for Robust Application of Systems Pharmacology.

Author

Gadkar K, Kirouac DC, Mager DE, van der Graaf PH, and Ramanujan S

Subjects
Humans, Computational Biology methods, Database Management Systems, Pharmacology, Clinical methods, Systems Biology methods, Workflow
Abstract

Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate success of QSP is the establishment of commonly accepted language, technical criteria, and workflows. We propose an integrated workflow that bridges conceptual objectives with underlying technical detail to support the execution, communication, and evaluation of QSP projects., (© 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.)

Published
2016
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3. Systems pharmacology for drug discovery and development: paradigm shift or flash in the pan?

Author

Vicini P and van der Graaf PH

Subjects
Animals, Computer Simulation, Drug Design, Humans, Models, Biological, Drug Discovery methods, Pharmacology methods, Systems Biology methods
Abstract

Systems pharmacology is an emerging approach that sets out to use quantitative concepts rooted in the synergy between modeling and simulation on one hand and large-scale data collection and analysis on the other to investigate biological systems and design therapeutic interventions. Interest in this field has recently increased substantially, but so have perceived challenges and misunderstandings, especially related to implementation. This Commentary explores the opportunities and challenges in the rapidly evolving area of systems pharmacology from a drug discovery and development perspective.

Published
2013
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