1. Tumor-infiltrating CD226+CD8+ T cells are associated with postoperative prognosis and adjuvant chemotherapeutic benefits in gastric cancer patients.
- Author
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Zhang, Yu, Zhao, Zhen-xiong, Gao, Jian-peng, Huang, Ya-kai, and Huang, Hua
- Subjects
STOMACH cancer ,T cells ,CANCER patients ,IMMUNOTHERAPY ,CANCER chemotherapy ,ADJUVANT chemotherapy - Abstract
Purpose: Defining the phenotypic characteristics of CD8
+ T cell subsets in gastric cancer (GC) can help remodel the immune microenvironment of the tumor, thereby improving patient prognosis. CD226 has recently been shown to regulate the activity of CD8+ T cell in several malignancies. However, the clinical relevance of CD226+ CD8+ T cells in GC remains unclear. Methods: Fudan University Shanghai Cancer Center (FUSCC) cohort (n = 316), The Cancer Genome Atlas (TCGA) cohort (n = 407), KUGH/KUCM cohort (n = 202), and Asian Cancer Research Group (ACRG) cohort (n = 300) were included in prognosis and response to adjuvant chemotherapy (ACT) analyses. Flow cytometry and multiplex immunostaining were used to characterize CD226+ CD8+ T cells. Results: CD226+ CD8+ T cells predicted favorable outcomes in patients undergoing curative resection for GC. GC patients with high CD226+ CD8+ T cell infiltration benefitted more from adjuvant chemotherapy. CD155 is upregulated in GC tissues and is associated with decreased intra-tumoral CD226+ CD8+ T cell infiltration. The combination of intra-tumoral CD226+ CD8+ T cells and CD155 is a strong prognostic predictor in patients with GC. Conclusion: CD226+ CD8+ T cells may represent a novel therapeutic target and a useful marker of prognosis and therapeutic response in patients with GC. [ABSTRACT FROM AUTHOR]- Published
- 2023
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