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1. Role of targeted therapy in the treatment of HER-2-positive breast cancer brain metastases

Author

G. A. Dashyan, V. F. Semiglazov, P. V. Krivorot’ko, T. Yu. Semiglazova, E. E. Topuzov, R. M. Paltuev, K. Yu. Zernov, V. S. Apollonova, S. S. Ereshchenko, A. V. Petrova, E. K. Zhil’tsova, and O. A. Ivanova

Subjects
her-2-positve breast cancer, central nervous system metastases, t-dm1, Gynecology and obstetrics, RG1-991
Abstract

Brain metastases are detectable in 25–35 % of patients with progressive HER-2-positve breast cancer. Even after spreading metastases into the brain, chemotherapy in combination with anti-HER- 2 therapy improves survival due to better control of the systemic disease. The paper presents the results of investigations substantiating the use of anti-HER-2 targeting agents, as well as the innovative agent T-DM1 to treat brain metastases.

Published
2016
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