1. Insecticidal bisindole alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'.
- Author
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Chen J, Kongkiatpaiboon S, and Cai XH
- Subjects
- Animals, Molecular Structure, Sf9 Cells, Tabernaemontana chemistry, Plant Leaves chemistry, Insecticides chemistry, Insecticides pharmacology, Insecticides isolation & purification, Spodoptera drug effects, Indole Alkaloids chemistry, Indole Alkaloids isolation & purification, Indole Alkaloids pharmacology
- Abstract
Six undescribed bisindole alkaloids, namely taberdisines A-F (1-6), were isolated from the leaves of Tabernaemontana divaricata 'Dwaft'. Among them, alkaloids 1 and 2 were the first examples of strychnos-iboga type alkaloid with both C-C linkage patterns. Alkaloid 3, a new type of aspidosperma-iboga with a furan-ring, as well as other three undescribed ones was disclosed. Their structures were elucidated by comprehensive spectroscopic analyses. Alkaloids 1 and 5 showed insecticide activity on Sf9 cell and eggs of Spodoptera frugiperda in vivo, which might explain the potential of the plants for insect resistance., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper, (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
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