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2 results on '"Clara Grau"'

1. Personalised Tasted Masked Chewable 3D Printed Fruit-Chews for Paediatric Patients

Author

Atabak Ghanizadeh Tabriz, Daniel Henri George Fullbrook, Lilian Vilain, Youri Derrar, Uttom Nandi, Clara Grau, Anaïs Morales, Gemma Hooper, Zoltan Hiezl, and Dennis Douroumis

Subjects
personalised dosage forms, 3D printing, paediatric, flavours, sweeteners, taste masking, Pharmacy and materia medica, RS1-441
Abstract

The development of personalised paediatric dosage forms using 3D printing technologies has gained significant interest over the last few years. In the current study extruded filaments of the highly bitter Diphenhydramine Hydrochloride (DPH) were fabricated by using suitable hydrophilic carries such as hydroxypropyl cellulose (Klucel ELFTM) and a non-ionic surfactant (Gelucire 48/16TM) combined with sweetener (Sucralose) and strawberry flavour grades. The thermoplastic filaments were used to print 3D fruit-chew designs by Fused Deposition Modelling (FDM) technology. Physicochemical characterisation confirmed the formation of glass solution where DPH was molecularly dispersed within the hydrophilic carriers. DPH was released rapidly from the 3D printed fruit-chew designs with >85% within the first 30 min. Trained panellists performed a full taste and sensory evaluation of the sweetener intensity and the strawberry aroma. The evaluation showed complete taste masking of the bitter DPH and revealed a synergistic effect of the sweetener and the strawberry flavour with enhanced sweet strawberry, fruity and aftertaste perception. The findings of the study can be used for the development of paediatric dosage forms with enhanced organoleptic properties, palatability and medication adherence.

Published
2021
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2. Personalised Tasted Masked Chewable 3D Printed Fruit-Chews for Paediatric Patients

Author

Gemma Hooper, Lilian Vilain, Daniel Henri George Fullbrook, Zoltan Hiezl, Anaïs Morales, Atabak Ghanizadeh Tabriz, Youri Derrar, Dennis Douroumis, Uttom Nandi, and Clara Grau

Subjects
Taste, Sucralose, paediatric, Diphenhydramine hydrochloride, sensory evaluation, Organoleptic, Flavour, Pharmaceutical Science, Dosage form, Article, chemistry.chemical_compound, Pharmacy and materia medica, Food science, Aftertaste, sweeteners, Aroma, biology, Chemistry, technology, industry, and agriculture, food and beverages, flavours, personalised dosage forms, 3D printing, biology.organism_classification, taste masking, RS1-441, palatability
Abstract

The development of personalised paediatric dosage forms using 3D printing technologies has gained significant interest over the last few years. In the current study extruded filaments of the highly bitter Diphenhydramine Hydrochloride (DPH) were fabricated by using suitable hydrophilic carries such as hydroxypropyl cellulose (Klucel ELFTM) and a non-ionic surfactant (Gelucire 48/16TM) combined with sweetener (Sucralose) and strawberry flavour grades. The thermoplastic filaments were used to print 3D fruit-chew designs by Fused Deposition Modelling (FDM) technology. Physicochemical characterisation confirmed the formation of glass solution where DPH was molecularly dispersed within the hydrophilic carriers. DPH was released rapidly from the 3D printed fruit-chew designs with &gt, 85% within the first 30 min. Trained panellists performed a full taste and sensory evaluation of the sweetener intensity and the strawberry aroma. The evaluation showed complete taste masking of the bitter DPH and revealed a synergistic effect of the sweetener and the strawberry flavour with enhanced sweet strawberry, fruity and aftertaste perception. The findings of the study can be used for the development of paediatric dosage forms with enhanced organoleptic properties, palatability and medication adherence.

Published
2021

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