1. Accurate Estimation of Functional Liver Volume Using Gd-EOB-DTPA MRI Compared to MDCT/ 99m Tc-SPECT Fusion Imaging.
- Author
-
Morine Y, Enkhbold C, Imura S, Ikemoto T, Iwahashi S, Saito YU, Yamada S, Utsunomiya T, and Shimada M
- Subjects
- Adult, Aged, Aged, 80 and over, Asialoglycoprotein Receptor analysis, Biomarkers analysis, Biopsy, Female, Hepatectomy, Humans, Immunohistochemistry, Liver chemistry, Liver surgery, Male, Middle Aged, Organ Size, Organic Anion Transporters analysis, Predictive Value of Tests, Reproducibility of Results, Contrast Media administration & dosage, Gadolinium DTPA administration & dosage, Liver diagnostic imaging, Magnetic Resonance Imaging methods, Multidetector Computed Tomography, Radiopharmaceuticals administration & dosage, Single Photon Emission Computed Tomography Computed Tomography methods, Technetium Tc 99m Aggregated Albumin administration & dosage, Technetium Tc 99m Pentetate administration & dosage
- Abstract
Background/aim: We assessed the utility of dynamic magnetic resonance imaging (MRI) with gadoxetate-ethoxybenzyl-diethylenetriamine penta-aceticpenta-acetic acid (Gd-EOB-DTPA) (EOB-MRI) for estimating functional liver volume compared to
99m Tc-galactosyl albumin single-photon-emission computed tomography (99m Tc-GSA SPECT)., Patients and Methods: Regional functional liver volume (left lateral, medial, right anterior, right posterior) of 58 hepatectomized patients was assessed using EOB-MRI and99m Tc-GSA SPECT, and compared to the actual liver volume with MDCT-3D volumetry., Results:99m Tc-GSA SPECT found a significantly lower functional volume of the left lateral section than the actual volume found by MDCT-3D volumetry (p=0.003) and EOB-MRI (p<0.001). Functional liver volume of right anterior section found with99m Tc-GSA SPECT was significantly higher than that found by MDCT-3D volumetry (p=0.04), despite no differences in asialoglycoprotein receptor 1 (ASGR1) or ATP-dependent organic anion transporting polypeptide 1 (OATP) expression between the left lateral and right anterior sections., Conclusion:99m Tc-GSA SPECT might underestimate the function of the left lobe and overestimate that of the right lobe. Therefore, EOB-MRI could be better for estimating the true regional functional liver reserve., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)- Published
- 2017
- Full Text
- View/download PDF