1. Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions.
- Author
-
Chen S, Xing C, Huang D, Zhou C, Ding B, Guo Z, Peng Z, Wang D, Zhu X, Liu S, Cai Z, Wu J, Zhao J, Wu Z, Zhang Y, Wei C, Yan Q, Wang H, Fan D, Liu L, Zhang H, and Cao Y
- Subjects
- Animals, Antineoplastic Agents pharmacokinetics, Biomarkers, Cell Line, Tumor, Chemical Phenomena, Disease Models, Animal, Fluorescent Antibody Technique, Humans, Mice, Xenograft Model Antitumor Assays, Antineoplastic Agents administration & dosage, Drug Carriers chemistry, Metal Nanoparticles chemistry, Metal Nanoparticles ultrastructure, Selenium chemistry, Tellurium chemistry
- Abstract
Two-dimensional nanomaterial-based photothermal therapy (PTT) is currently under intensive investigation as a promising approach toward curative cancer treatment. However, high toxicity, moderate efficacy, and low uniformity in shape remain critical unresolved issues that hamper their clinical application. Thus, there is an urgent need for developing versatile nanomaterials to meet clinical expectations. To achieve this goal, we developed a stable, highly uniform in size, and nontoxic nanomaterials made of tellurium-selenium (TeSe)-based lateral heterojunction. Systemic delivery of TeSe nanoparticles in mice showed highly specific accumulation in tumors relative to other healthy tissues. Upon exposure to light, TeSe nanoparticles nearly completely eradicated lung cancer and hepatocellular carcinoma in preclinical models. Consistent with tumor suppression, PTT altered the tumor microenvironment and induced immense cancer cell apoptosis. Together, our findings demonstrate an exciting and promising PTT-based approach for cancer eradication., (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
- Published
- 2020
- Full Text
- View/download PDF