1. Total Synthesis of Jiadifenolide
- Author
-
Paterson, Ian, Xuan, Mengyang, Dalby, Stephen M, Paterson, Ian [0000-0002-8861-9136], and Apollo - University of Cambridge Repository
- Subjects
Vinyl Compounds ,cyclization ,Molecular Structure ,terpenoids ,neurological agents ,Stereoisomerism ,General Medicine ,samarium ,Crystallography, X-Ray ,total synthesis ,Oxidation-Reduction ,Sesquiterpenes ,Communications - Abstract
As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium-mediated cyclization reaction to establish the tricyclic core and the adjacent C5 and C6 quaternary stereocenters.
- Published
- 2014