1. Clinical outcomes of a novel combination of lenalidomide and rituximab followed by stem cell transplantation for relapsed/refractory aggressive B-cell non-hodgkin lymphoma
- Author
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Tongyu Lin, Liang Zhang, Huiqiang Huang, Yiming Chen, Elyse Lopez, Qingqing Cai, Shouhao Zhou, Wenqi Jiang, Maria Badillo, Jorge E. Romaguera, Dehui Zou, and Michael Wang
- Subjects
Oncology ,Male ,medicine.medical_specialty ,Lymphoma, B-Cell ,Kaplan-Meier Estimate ,Disease-Free Survival ,Antibodies, Monoclonal, Murine-Derived ,International Prognostic Index ,immune system diseases ,Internal medicine ,hemic and lymphatic diseases ,Clinical outcomes ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Relapsed lymphoma ,Lenalidomide ,Aged ,Retrospective Studies ,business.industry ,Stem cell transplantation ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Lymphoma ,Surgery ,Thalidomide ,Transplantation ,surgical procedures, operative ,B-Cell Non-Hodgkin Lymphoma ,Rituximab ,Mantle cell lymphoma ,Female ,Clinical Research Paper ,Neoplasm Recurrence, Local ,business ,therapeutics ,human activities ,medicine.drug - Abstract
We retrospectively compared outcomes of patients with relapsed/refractory non-Hodgkin lymphoma (NHL) who underwent stem cell transplantation (SCT) with stable disease or better following a novel combination of lenalidomide and rituximab (LR) treatment and did not undergo SCT in a phase I/II clinical trial. We retrospectively compared outcomes of patients who underwent SCT with that of patients who had stable disease or better following LR treatment and did not undergo SCT. Twenty-two patients enrolled in LR clinical trial and undergone SCT were identified, 13 with mantle cell lymphoma (MCL) and nine with large B-cell lymphoma (LBCL). All patients who underwent SCT achieved complete response. In the MCL subset, there were no significant differences between SCT and non-SCT groups except that non-SCT patients were older and had a higher mantle-cell international prognostic index score. There was no difference between SCT-group and non-SCT-group in response duration (P=0.3), progression-free survival (PFS) (P=0.304) and overall survival (OS) (P=0.87). In LBCL subgroup, there were no significant differences between two groups except that non-SCT group had a higher international prognostic index score. Patients with LBCL who underwent SCT had significantly longer response duration (P=0.001), PFS (P=0.000), and OS (P=0.003) than the non-SCT group. The novel therapeutic combination offers a bridge to SCT in patients with relapsed/refractory aggressive B-cell NHL.
- Published
- 2014