1. 5-HTT mRNA level as a potential biomarker of treatment response in patients with major depression in a clinical trial.
- Author
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Kao, Wei-Tsung, Chang, Chen-Lin, and Lung, For-Wey
- Subjects
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MENTAL depression , *MESSENGER RNA , *BIOMARKERS , *SEROTONIN transporters , *CLINICAL trials , *ANTIDEPRESSANTS , *PAROXETINE , *ALLELES , *COMPARATIVE studies , *GENETIC polymorphisms , *HAMILTON Depression Inventory , *RESEARCH methodology , *MEDICAL cooperation , *MEMBRANE proteins , *PSYCHOLOGICAL tests , *RESEARCH , *RNA , *TIME , *EVALUATION research , *TREATMENT effectiveness , *GENOTYPES , *THERAPEUTICS - Abstract
Objectives: To investigate whether the serotonin transporter (5-HTT or SERT or SLC6A4) mRNA level could be used as a biomarker of treatment response in patients with major depression treated with different antidepressants while controlling related factors.Methods: One hundred and nineteen patients with major depression were recruited; all genotyped for the 5-HTT polymorphism concerning 5-HTTLPR, rs25531, and STin2 VNTR, provided demographic data and completed relevant questionnaires. Duloxetine and paroxetine were administered over 32 weeks to these patients. The Hamilton depression rating scale (HDRS) and 5-HTT mRNA level were evaluated at baseline (Week 0), and at 8, 16, 24 and 32 weeks.Results: Improvement in depressive symptoms (HDRS score declined) and increasing in 5-HTT mRNA level were found with longer duration of antidepressant treatment in patients with major depression. Patients with more 5-HTTPR long-form alleles and STin2.12 alleles had poor antidepressant treatment response. Duloxetine may give a better treatment response than paroxetine. Using structural equation modeling (SEM), the 5-HTTLPR long-form had a direct positive association with the 5-HTT mRNA level and an indirect adverse relationship with the 5-HTT mRNA level through neuroticism and previous suicide attempts.Conclusion: The 5-HTT mRNA level increased and correlated with the treatment response (HDRS score improvement) under 32-weeks antidepressants treatment clinical trial. We speculate that the 5-HTT mRNA level may be used as a potential biomarker of antidepressant treatment response. [ABSTRACT FROM AUTHOR]- Published
- 2018
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