Search

Eosinophilic oesophagitis (EO) is a chronic immune/ antigen-mediated oesophageal disease, with the immune reaction most likely directed to foods but on occasion also to aeroallergens. Clinically, it is characterised by symptoms of oesophageal dysfunction in subjects who typically have other indicators of an atopic tendency. Older children (and adults) frequently present with dysphagia and can have strictures (which may require dilatation). The diagnosis is dependent on an eosinophilpredominant oesophageal inflammation, with 15 or more eosinophils per high-powered field, now generally accepted as a necessary cut-off level of infiltration, which together with other clinical data (eg, oesophageal pH/impedance studies) can help discriminate EO from other potential causes of symptoms such as gastrooesophageal reflux disease. Recommended therapies, which may need to be long term, are dietary antigen exclusion (with elemental feeds or an exclusion diet) and/or topical corticosteroids. [ABSTRACT FROM AUTHOR]

The article presents two case studies of 6- and 14-years old boy who suffered from Moore-Federman syndrome that manifested dwarfism in them. The symptoms were included short stature, joint stiffness, hypermetropia, and asthma. Both of them showed a slight increase in their height after the treatment with growth hormone. However, the intelligence level was normal. The syndrome resembles acromicric dysplasia.