1. Self-Expanding Metal Stents Improve Swallowing and Maintain Nutrition During Neoadjuvant Therapy for Esophageal Cancer.
- Author
-
Smith, Zachary, Gonzaga, Jason, Haasler, George, Gore, Elizabeth, Dua, Kulwinder, Smith, Zachary L, Gonzaga, Jason E, Haasler, George B, Gore, Elizabeth M, and Dua, Kulwinder S
- Subjects
SURGICAL stents ,DEGLUTITION disorders ,NUTRITION ,ADJUVANT treatment of cancer ,TREATMENT of esophageal cancer ,THERAPEUTICS ,DIET therapy ,BODY weight ,CHEST pain ,COMBINED modality therapy ,DEGLUTITION ,DIGESTIVE organ surgery ,ESOPHAGEAL tumors ,LONGITUDINAL method ,COMPLICATIONS of prosthesis ,SERUM albumin ,PILOT projects ,SEVERITY of illness index ,NUTRITIONAL status ,DISEASE complications ,EQUIPMENT & supplies ,TUMOR treatment - Abstract
Background: Patients with locally advanced esophageal cancer can have significant dysphagia. Nutritional support during neoadjuvant therapy is often delivered via nasoenteric or percutaneous feeding tubes. These approaches do not allow for per-oral feeding.Aims: Evaluate the safety and efficacy of fully covered self-expanding metal esophageal stents for nutritional support during neoadjuvant therapy.Methods: This was a pilot, prospective study at a single tertiary center. From March 2012 to May 2013, consecutive patients with esophageal cancer eligible for neoadjuvant therapy were enrolled. Metal stents were placed prior to starting neoadjuvant therapy. Data were collected at baseline and predetermined intervals until an endpoint (surgery or disease progression). Outcomes included dysphagia grade, satisfaction of swallowing score, nutritional status (weight, serum albumin), impact on surgery, and adverse events.Results: Fourteen stents were placed in 12 patients (59.1 ± 9.5 years, 11 men, 1 woman). Dysphagia grade (pre 3.4 ± 0.5 vs post 0.2 ± 0.4, p < 0.0001) and swallowing scores (20.2 ± 5.9 vs 6.3 ± 4.7, p < 0.0001) significantly improved after stent placement. Improvements were sustained throughout neoadjuvant therapy. Body weight and serum albumin levels remained stable. Adverse events included severe chest pain (2), food impaction (1), and delayed stent migration (2). Five patients underwent surgical resection. No significant chemoradiation or operative adverse events occurred due to the presence of a stent.Conclusions: During neoadjuvant therapy for esophageal cancer, self-expanding metal stents are safe and effective in relieving dysphagia and maintaining nutrition. They allow patients to eat orally, thereby improving patient satisfaction. The presence of an in situ stent did not interfere with surgery. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF