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The aim of this study was to compare the efficacy and adverse effects of a 595-nm pulsed dye laser therapy alone (PDL alone) with a 5-aminolevulinic (5-ALA) local application followed by a 595-nm PDL (5-ALA PDL) in the treatment of superficial hemangioma (SH). A prospectively randomized study in 181 patients with SH was carried out over a period of 24 months. One hundred and ninety-three patients were seen. One hundred and eighty-one patients with SH were enrolled, of which 165 completed final follow-up. One hundred and nineteen patients received PDL alone and 46 received 5-ALA PDL. The patients were assessed clinically and the patient's parents were given a satisfaction questionnaire. Baseline patient data (gender, lesion size, lesion site, treatment times, cure rate, and adverse reactions) were recorded and the results of the treatment of the two groups were analyzed and compared. Complete clearing of the lesion (recovery grade 4) was achieved in 44/119 (37.0%) of the PDL alone group and 31/46 (67.4%) of the 5-ALA PDL group (X 2 = 10.30, p < 0.001). Atrophic scars, hyper- and hypopigmentation occurred in both groups (X 2 = 3.32, p = 0.564). The patients' parents' satisfaction was greater in the 5-ALA PDL group. The clinical outcome of 5-ALA PDL was superior to that of PDL alone in the treatment of SH and only minor adverse events occurred in each group. [ABSTRACT FROM AUTHOR]

Background: The 595 nm tunable pulsed dye laser has been used in China for more than 10 years. However, no studies about its effect and side-effect in treatment of superficial hemangioma have been documented. Objective: This study was designed to retrospectively summarize its usage in Chinese patients. Methods: Infant patients with superficial hemangioma, who had received 595 nm tunable pulsed dye laser treatment in our laser center in the last 10 years, were recruited. Detailed demographics, results of assessment about their degree of clearance and clinical examination for treatment complications were entered into SASS10.0 version database, and statistical analyses were conducted. Results: Six hundred and fifty-seven cases with superficial hemangioma were recruited. The overall effectiveness rate was 91.17%. Female patients respond better than male, the difference was statistically significant ( p < 0.001). Lesions at different part of the body respond differently to the treatment with lesions on extremities show the best result. The response rate does not increase with time of treatments. The most common side-effects were pigment changes and skin atrophy, which usually resolve spontaneously and disappear completely in a few months. Conclusions: Our experience confirmed the satisfactory clinical efficacy and safety of the 595 nm tunable pulse dye laser in the treatment of childhood superficial hemangioma. [ABSTRACT FROM AUTHOR]

Pyogenic granuloma (PG) is a common vascular tumor that can be treated using various means. However, some large lesions and those located on some difficult-to-treat body sites may represent a formidable selection to the clinician because of the residual pain after treatment, difficulties in surgical excision at one trial and covering with one dressing, and the risk of sequelae. We report a successful treatment of such a giant lesion that arises in the scar which was left because of port wine stain, using a Nd/YAG holmium pulsed dye laser. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate the effect and safety of the holmium: YAG laser in the treatment of facial recalcitrant verruca vulgaris. Methods: 42 patients with recalcitrant facial verruca vulgaris (64 warts in all) were enrolled in the study. Warts were treated with holmium: YAG pulsed dye laser with a top energy of 1.2-1.5 J, pulse frequency 10-12 Hertz, average power 10 Watt. Adverse reaction, complication, recurrence and clinical assessment of the lesion were documented with follow-up 6 months. Results: Ages of patients ranged from 16 to 73 years. 62 warts in 42 patients were eliminated by only one treatment session. The average time for wound-healing is 10.3 days. No severe discomfort, bleeding, edema, ulceration and secondary infection developed. No obvious complications were found. Only 4 warts in 3 patients remained mild atrophy scar and 7 warts in 6 patients remained pigment change. These defects became slighter after 6-month follow-up and left no bad effect on aesthetic. Two of the patients encountered recurrence in the treated site follow-up 6 months. Conclusions: Holmium laser is an effective and safe therapy for recalcitrant verruca vulgaris. It is the choice of treatment for those lesions in cosmetically sensitive areas. [ABSTRACT FROM AUTHOR]