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Background: Sarcoidosis, characterized by non-caseating epithelioid granulomas, presents diagnostic and therapeutic challenges. Method: Here we present a 38-year-old woman who exhibited erythematous and infiltrated skin lesions on her facial region following fractional laser treatment. Results: Histological analysis confirmed cutaneous sarcoidosis. Initial interventions with topical clobetasol and oral chloroquine provided transient relief. Subsequent outpatient management comprised topical tacrolimus and clobetasol, as well as systemic methotrexate, later substituted with prednisone. Gradual tapering resulted in lesion reduction. Conclusions: This case underscores the intricate nature of cutaneous sarcoidosis and the necessity for personalized therapeutic approaches. The association with cosmetic procedures highlights the importance of understanding potential triggers. The presented case highlights and reminds the medical community that lasers are not only used for therapeutic purposes but can also induce specific responses through laser therapy. Notably, while laser therapy is frequently employed in treating cutaneous sarcoidosis, its role in inducing sarcoidosis warrants further investigation. [ABSTRACT FROM AUTHOR]

The article discusses the case of a 77-year-old man in Poland who exhibited chronic tuberculosis (TB) luposa, or TB of the skin. It mentions that long, repeated isoniazid monotherapy failed to cure the patient's extensive skin lesions. A DNA amplification test was performed in order to rule out the possibility that vaccination may have caused a positive tuberculin skin test result. Combining isoniazid with other TB drugs to prevent drug resistance is also addressed.