1. Anlotinib enhances the antitumor activity of radiofrequency ablation on lung squamous cell carcinoma
- Author
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Yaqi Tong, Yanming Li, Yunzhi Zhou, Yongping Gao, Wei Zhou, and Qingjun Wu
- Subjects
0301 basic medicine ,Indoles ,Lung Neoplasms ,Radiofrequency ablation ,Mice, Nude ,Antineoplastic Agents ,Receptor tyrosine kinase ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,law ,Cell Line, Tumor ,Animals ,Humans ,Medicine ,Protein Kinase Inhibitors ,Pharmacology ,Radiofrequency Ablation ,Lung ,biology ,Kinase ,business.industry ,Lung squamous cell carcinoma ,medicine.disease ,Combined Modality Therapy ,In vitro ,surgical procedures, operative ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Quinolines ,biology.protein ,Cancer research ,Adenocarcinoma ,business ,Protein Kinases ,therapeutics ,Respiratory tract - Abstract
Anlotinib is a novel molecular targeted drug that has been approved for the treatment of lung adenocarcinoma. Currently these agents are rarely used in the treatment of lung squamous cell carcinoma (LSCC). Bronchoscope-guided radiofrequency ablation (RFA) is a new strategy proposed for the treatment of LSCC that is able to alleviate the obstruction of the respiratory tract caused by LSCC by direct destruction of the tumor tissues. The presence work aims to reveal whether Anlotinib could enhance the antitumor activity of RFA on LSCC cells. The results from real-time PCR (qPCR) confirmed overexpression of targets of anlotinib activity, including receptor tyrosine kinase or the MPAK/PI3K-AKT pathway kinases, in LSCC tissues. Treatment with anlotinib inhibited the survival, in vitro invasion, and migration of LSCC cells. Moreover, the antitumor effects of RFA were investigated using a rodent model of LSCC. The combination of RFA and anlotinib treatment enhanced the antitumor effect of RFA treatment. We propose a combinative strategy of RFA and anlotinib as a novel approach for successful management of LSCC.
- Published
- 2021