1. Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer
- Author
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Jin Woong Kim, Jun-Eul Hwang, Young-Kyu Park, Sung-Hoon Jung, Seung-Hun Kim, Sang-Hee Cho, Hyun-Jeong Shim, Eu Chang Hwang, Ik-Joo Chung, Sang-Soo Shin, Joon Jin, Min-Jee Kim, Oh Jeong, Ji-Yun Hong, and Woo Kyun Bae
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Percutaneous ,Radiofrequency ablation ,medicine.medical_treatment ,Stomach neoplasms ,Catheter ablation ,Kaplan-Meier Estimate ,Adenocarcinoma ,Gastroenterology ,Metastasis ,law.invention ,law ,Surgical oncology ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Chemotherapy ,Aged ,Aged, 80 and over ,business.industry ,Liver Neoplasms ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Surgery ,surgical procedures, operative ,Oncology ,Catheter Ablation ,Female ,business ,therapeutics ,Research Paper - Abstract
This study evaluated the efficacy of percutaneous radiofrequency ablation (RFA) for the treatment of metachronous liver metastases of gastric cancer. We enrolled a total of 44 patients who underwent percutaneous RFA for the treatment of metachronous liver metastases after resection of a primary gastric adenocarcinoma from January 2002 to November 2011. The primary endpoint of this study was overall survival (OS) and recurrence-free survival (RFS) after RFA. Systemic chemotherapy was combined with RFA in 40 patients; the OS and RFS of the patients with liver-only metastasis who underwent RFA and chemotherapy were 20.9 months (95 % CI 18.4–23.4) and 9.8 months (95 % CI 9.2–10.5), respectively. On multivariate analysis, the factors independently, negatively associated with OS were extrahepatic metastatic lesions (HR 12.6, 95 % CI 3.7–42.9; p = 0.001), no chemotherapy (HR 43.3, 95 % CI 7.4–251.3; p = 0.001), and tumor number ≥2 (HR 2.6, 95 % CI 1.2–5.9; p = 0.015). The factors independently, negatively associated with RFS were extrahepatic metastatic lesions (HR 3.6, 95 % CI 1.6–7.8; p = 0.003) and bilobar intrahepatic distribution (HR 3.9, 95 % CI 1.5–9.9; p = 0.001). The efficacy of percutaneous RFA for metachronous liver metastases of gastric cancer is limited to patients with a single, unilobar metastasis without extrahepatic metastatic lesions. Combined systemic chemotherapy is very important for the prolongation of OS.
- Published
- 2013