1. Rational design of novel water-soluble ampholytic cellulose derivatives
- Author
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Nicolas Brun, Naglaa Salem El-Sayed, Peter Hesemann, Samir Kamel, Mohamed El-Sakhawy, Cellulose and Paper Department, National Research Center [Dokki, Egypt], Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
- Subjects
02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Retina ,Cell Line ,Butyric acid ,chemistry.chemical_compound ,Structural Biology ,Materials Testing ,Nucleophilic substitution ,Organic chemistry ,Humans ,MTT assay ,Thermal stability ,Fourier transform infrared spectroscopy ,Cellulose ,Molecular Biology ,ComputingMilieux_MISCELLANEOUS ,Esterification ,Rational design ,General Medicine ,[CHIM.MATE]Chemical Sciences/Material chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Microcrystalline cellulose ,chemistry ,Succinic acid ,0210 nano-technology - Abstract
The development of new biocompatible, biodegradable functionalized biopolymers that can serve as scaffold for tissue regeneration or work as carriers for different bioactive molecules such as drugs, proteins, and enzymes remains a continuous challenge that need to be extensively explored. For this purpose, three water-soluble cellulose derivatives; namely 4(celluloseamino) butyric acid (CABA) 2(celluloseamino) succinic acid (CASA), and 3(celluloseamino) propane sulfonic acids (CAPSA) were synthesized from microcrystalline cellulose (MCC) via esterification with tosyl chloride that was followed by nucleophilic substitution by the proper aminoalkyl acid derivative. The products were characterized by elemental analyses, FTIR, 13C NMR spectroscopy. The thermal stability, surface morphology, and the elemental composition of the new ampholytic biopolymers were also studied by TGA, EDX-SEM. The new ampholytic cellulose derivatives were evaluated for their in vitro cytotoxicity on normal human retina cell line (RPE1) by MTT assay.
- Published
- 2018