1. Current understanding and future implications of sepsis-induced thrombocytopenia.
- Author
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Ghimire S, Ravi S, Budhathoki R, Arjyal L, Hamal S, Bista A, Khadka S, and Uprety D
- Subjects
- Animals, Blood Coagulation, Blood Platelets metabolism, Disease Management, Humans, Thrombocytopenia blood, Thrombocytopenia diagnosis, Thrombocytopenia therapy, Thrombopoiesis, Disease Susceptibility immunology, Sepsis complications, Thrombocytopenia etiology
- Abstract
Sepsis is a global health burden that needs intensive medical care. Thrombocytopenia in sepsis is well known to increase morbidity as well as mortality. Several studies have been performed both in animal models and in humans to understand the mechanism by which sepsis causes thrombocytopenia. Recent studies have shown that inhibiting thrombocytopenia improves outcomes in sepsis patients. Understanding these mechanisms to identify targets in use of newer treatment modalities besides using resuscitation measures, antibiotics and removal of thrombocytopenia inducing agent could potentially help us improve outcomes in sepsis., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2021
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