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In the present work, we report the synthesis of six new azomethine linkage containing dihydroxy derivatives of carvacrol, thymol, and eugenol. All the synthesized derivatives have been characterized by spectroscopic techniques and their structures were confirmed by X-ray single crystallography. Synthesized derivatives were screened for anti-oxidant activity using DPPH radical scavenging assay, and anticancer activity by using SRB assay against pancreatic cancer with MIAPaCa-2 and colon cancer with HCT-15 cell lines. The molecular docking studies of all the synthesized derivatives were performed on cyclooxygenases (COX-2) protein enzyme. In the anti-oxidant test, the values of EC indicated that all the compounds show excellent anti-oxidant potency, and similarly the GI values in anticancer tests indicated that most of the compounds possess good anticancer efficacy. The overall docking score suggested that all the synthesized compounds exhibit good binding affinity towards cyclooxygenases (COX-2) protein enzyme. Graphical Abstract: [ABSTRACT FROM AUTHOR]

Carvacrol and thymol are well-known phenolic monoterpenoids present as functional ingredients in numerous products. Keeping the diverse therapeutic activities of phenolic monoterpenes in mind, we attempted to synthesize a new series of acetohydrazone linkage containing carvacrol and thymol derivatives. All synthesized derivatives were characterized by spectroscopic techniques. Finally, all the derivatives were screened for their anti-oxidant activities by using DPPH assay, and anticancer activities by using SRB assay against pancreatic cancer with the MIAPaCa-2 cell line and colon cancer with the HCT-15 cell line. Themolecular docking studies of all the synthesized derivatives were carried out on the cyclooxygenase-2 (COX-2) protein enzyme. In the anti-oxidant test, EC values of all the compounds showed excellent anti-oxidant potency, and similarly the values of GI in the anticancer test displayed that most of the compounds possess good anticancer potency. Total docking results suggested that all the synthesized compounds exhibit good binding affinity towards receptors. Graphical Abstract: [ABSTRACT FROM AUTHOR]