5 results on '"Gallina, Filippo Tommaso"'
Search Results
2. Robotic thymectomy in thymic tumours: a multicentre, nation-wide study.
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Comacchio, Giovanni Maria, Schiavon, Marco, Zirafa, Carmelina Cristina, Palma, Angela De, Scaramuzzi, Roberto, Meacci, Elisa, Bongiolatti, Stefano, Monaci, Nicola, Lyberis, Paraskevas, Novellis, Pierluigi, Brandolini, Jury, Parini, Sara, Ricciardi, Sara, D'Andrilli, Antonio, Bottoni, Edoardo, Gallina, Filippo Tommaso, Marino, Maria Carlotta, Lorenzoni, Giulia, Francavilla, Andrea, and Rendina, Erino Angelo
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THYMECTOMY ,MYASTHENIA gravis ,SURGICAL complications ,TUMORS ,ROBOTICS ,DEMOGRAPHIC characteristics - Abstract
OBJECTIVES Robotic thymectomy has been suggested and considered technically feasible for thymic tumours. However, because of small-sample series and the lack of data on long-term results, controversies still exist on surgical and oncological results with this approach. We performed a large national multicentre study sought to evaluate the early and long-term outcomes after robot-assisted thoracoscopic thymectomy in thymic epithelial tumours. METHODS All patients with thymic epithelial tumours operated through a robotic thoracoscopic approach between 2002 and 2022 from 15 Italian centres were enrolled. Demographic characteristics, clinical, intraoperative, postoperative, pathological and follow-up data were retrospectively collected and reviewed. RESULTS There were 669 patients (307 men and 362 women), 312 (46.6%) of whom had associated myasthenia gravis. Complete thymectomy was performed in 657 (98%) cases and in 57 (8.5%) patients resection of other structures was necessary, with a R0 resection in all but 9 patients (98.6%). Twenty-three patients (3.4%) needed open conversion, but no perioperative mortality occurred. Fifty-one patients (7.7%) had postoperative complications. The median diameter of tumour resected was 4 cm (interquartile range 3–5.5 cm), and Masaoka stage was stage I in 39.8% of patients, stage II in 56.1%, stage III in 3.5% and stage IV in 0.6%. Thymoma was observed in 90.2% of patients while thymic carcinoma occurred in 2.8% of cases. At the end of the follow-up, only 2 patients died for tumour-related causes. Five- and ten-year recurrence rates were 7.4% and 8.3%, respectively. CONCLUSIONS Through the largest collection of robotic thymectomy for thymic epithelial tumours we demonstrated that robot-enhanced thoracoscopic thymectomy is a technically sound and safe procedure with a low complication rate and optimal oncological outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Ergonomic Assessment of Robotic versus Thoracoscopic Thymectomy.
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Taje, Riccardo, Peer, Michael, Gallina, Filippo Tommaso, Ambrogi, Vincenzo, Sharbel, Azzam, Melis, Enrico, Elia, Stefano, Idit, Matot, Facciolo, Francesco, Patirelis, Alexandro, Sorge, Roberto, and Pompeo, Eugenio
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THYMECTOMY ,CHEST endoscopic surgery ,SURGICAL complications ,PROPENSITY score matching ,SURGICAL robots ,ROBOTICS - Abstract
Introduction: Robotic and thoracoscopic surgery are being increasingly adopted as minimally invasive alternatives to open sternotomy for complete thymectomy. The superior maneuverability range and three-dimensional magnified vision are potential ergonomical advantages of robotic surgery. To compare the ergonomic characteristics of robotic versus thoracoscopic thymectomy, a previously developed scoring system based on impartial findings was employed. The relationship between ergonomic scores and perioperative endpoints was also analyzed. Methods: Perioperative data of patients undergoing robotic or thoracoscopic complete thymectomy between January 2014 and December 2022 at three institutions were retrospectively retrieved. Surgical procedures were divided into four standardized surgical steps: lower-horns, upper-horns, thymic veins and peri-thymic fat dissection. Three ergonomic domains including maneuverability, exposure and instrumentation were scored as excellent(score-3), satisfactory(score-2) and unsatisfactory(score-1) by three independent reviewers. Propensity score matching (2:1) was performed, including anterior mediastinal tumors only. The primary endpoint was the total maneuverability score. Secondary endpoints included the other ergonomic domain scores, intraoperative adverse events, conversion to sternotomy, operative time, post-operative complications and residual disease. Results: A total of 68 robotic and 34 thoracoscopic thymectomies were included after propensity score matching. The robotic group had a higher total maneuverability score (p = 0.039), particularly in the peri-thymic fat dissection (p = 0.003) and peri-thymic fat exposure score (p = 0.027). Moreover, the robotic group had lower intraoperative adverse events (p = 0.02). No differences were found in residual disease. Conclusions: Robotic thymectomy has shown better ergonomic maneuverability compared to thoracoscopy, leading to fewer intraoperative adverse events and comparable early oncological results. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Thymic Epithelial Tumors as a Model of Networking: Development of a Synergistic Strategy for Clinical and Translational Research Purposes.
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Melis, Enrico, Gallo, Enzo, di Martino, Simona, Gallina, Filippo Tommaso, Laquintana, Valentina, Casini, Beatrice, Visca, Paolo, Ganci, Federica, Alessandrini, Gabriele, Caterino, Mauro, Cecere, Fabiana Letizia, Mandoj, Chiara, Papadantonakis, Arianna, De Bello, Nicoletta, Lattanzio, Rossano, Palmieri, Giovannella, Garassino, Marina Chiara, Girard, Nicolas, Conti, Laura, and Blandino, Giovanni
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EPITHELIAL tumors ,TRANSLATIONAL research ,THYMUS tumors ,CANCER invasiveness ,EPITHELIAL cells ,AUTOIMMUNE diseases - Abstract
Among the group of thymic epithelial tumors (TET), thymomas often show either uncertain or explicit malignant biological behavior, local invasiveness, and intrathoracic relapse and are often difficult to manage. From the initial stages, thymic carcinomas tend to show aggressive behavior and extrathoracic spread. Moreover, the interplay of epithelial cells and thymocytes in thymomas causes complex immune derangement and related systemic autoimmune diseases. Due to their rare occurrence and to the limited funding opportunities available for rare tumors, it is challenging to make advances in clinical and translational research in TET. The authors of this paper are all members of a multidisciplinary clinical and research thoracic tumor team. Strong input was given to the team by long-standing expertise in TET in the Pathology Department. In addition, thanks to the collaboration between research units at our Institute as well as to national collaborations, over the last 10 years we were able to perform several tissue-based research studies. The most recent studies focused on microRNA and on functional studies on the thymic carcinoma cell line 1889c. The recent implementation of our biobank now provides us with a new tool for networking collaborative research activities. Moreover, the participation in a worldwide community such as ITMIG (International Thymic Malignancy Interest Group) has allowed us to significantly contribute toward fundamental projects/research both in tissue-based studies (The Cancer Genome Atlas) and in clinical studies (TNM staging of TET). Our achievements derive from constant commitment and long-standing experience in diagnosis and research in TET. New perspectives opened up due to the establishment of national [the Italian Collaborative Group for ThYmic MalignanciEs (TYME)] and European reference networks such as EURACAN, for an empowered joint clinical action in adult solid rare tumors. The challenge we face still lies in the advancement of clinical and basic science in thymic epithelial malignancies. [ABSTRACT FROM AUTHOR]
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- 2020
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5. Sternal wound dehiscence after median sternotomy: An alternative closure technique.
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Gallina, Filippo Tommaso, Melis, Enrico, Forcella, Daniele, and Facciolo, Francesco
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WOUNDS & injuries , *SURGICAL complications , *THYMOMA , *SUTURING , *ORTHOPEDIC implants , *THORACIC surgery , *TREATMENT effectiveness , *SURGICAL wound dehiscence , *SURGICAL site infections ,STERNUM surgery - Abstract
The conventional technique to close the sternal wound is characterized by the cerclage using steel wires.2 This procedure, in patient older than 65 years old, with a higher risk of osteopenia and osteoporosis, is traumatic and could lead to dehiscence of sternal wound, with or without mediastinitis.3 In our experience, after a sternal wound dehiscence in a high risk patient, we used an alternative sternal closure using a Goretex strips that protect the intercostal spaces parasternally. We close the sternal wound with the steel wires, but, we add an intercostal space reinforcement parasternally to avoid other dehiscence. [Extracted from the article]
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- 2021
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