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Background: Resveratrol is one of the most effective natural polyphenolic compounds synthesized by plants and its beneficial effects on glycemic control have been reported. Considering the prevalence of thyroid disorders in diabetic patients and the effect of resveratrol on metabolic pathway through Sirtuin1 receptors and its ability to change iodine absorption in thyroid gland, it is suspected that this compound might influence thyroid function and possible have goitrogenic effects. Materials and Methods: This study enrolled 50 subjects with type II diabetes in an intervention and a control group. Patients received 500 mg resveratrol capsules twice a day for 45 days and subjects in the control group received equivalent placebo capsules. Thyroid function tests including T3, T4, TSH and T3RU and anti TPO were checked just before the study and after 45 days. Results: Regarding past history and clinical and biochemical parameters including BMI, blood pressure and glycemic control, there was almost no significant difference between the two groups. Anti TPO levels did not significantly change between the two groups during the study. Finally changes between the two groups were compared using Mann-Whitney U test, which concluded significant changes only in T4 levels between the two groups during the course of the study. Conclusion: We can conclude that taking resveratrol 1 gr a day for 45 days as a supplementary for lowering blood glucose in patients with type II diabetes does not cause goitrogenic effects. Further studies are suggested on resveratrol effects on thyroid function in humans with different doses and durations. Moreover, it is suggested that subjects with known thyroid disease with existing underlying pathology be studied to better understand its effects on thyroid function. [ABSTRACT FROM AUTHOR]

Background: Resveratrol is one of the most effective natural polyphenolic compounds synthesized by plants and its beneficial effects on glycemic control have been reported. Considering the prevalence of thyroid disorders in diabetic patients and the effect of resveratrol on metabolic pathway through Sirtuin1 receptors and its ability to change iodine absorption in thyroid gland, it is suspected that this compound might influence thyroid function and possible have goitrogenic effects. Materials and Methods: This study enrolled 50 subjects with type II diabetes in an intervention and a control group. Patients received 500 mg resveratrol capsules twice a day for 45 days and subjects in the control group received equivalent placebo capsules. Thyroid function tests including T3, T4, TSH and T3RU and anti TPO were checked just before the study and after 45 days. Results: Regarding past history and clinical and biochemical parameters including BMI, blood pressure and glycemic control, there was almost no significant difference between the two groups. Anti TPO levels did not significantly change between the two groups during the study. Finally changes between the two groups were compared using Mann-Whitney U test, which concluded significant changes only in T4 levels between the two groups during the course of the study. Conclusion: We can conclude that taking resveratrol 1 gr a day for 45 days as a supplementary for lowering blood glucose in patients with type II diabetes does not cause goitrogenic effects. Further studies are suggested on resveratrol effects on thyroid function in humans with different doses and durations. Moreover, it is suggested that subjects with known thyroid disease with existing underlying pathology be studied to better understand its effects on thyroid function. [ABSTRACT FROM AUTHOR]