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Start Over Author "Jing-Jia Wang" Topic thyrotropin
3 results on '"Jing-Jia Wang"'

1. Association Between Thyroid Dysfunction and Incidence of Atrial Fibrillation in Patients With Hypertrophic Obstructive Cardiomyopathy

Author

Xiangbin Meng, Xu-Liang Wang, Zhi-yuan Zhang, Kuo Zhang, Jun Gao, Ji-lin Zheng, Jing-Jia Wang, Yu-peng Liu, Jie Yang, Chen Li, Yi-Tian Zheng, Chunli Shao, Wen-Yao Wang, and Yi-Da Tang

Subjects
Endocrinology, Diabetes and Metabolism, Incidence, Atrial Fibrillation, Thyroid Gland, Humans, Thyrotropin, Cardiomyopathy, Hypertrophic
Abstract

ObjectiveTo explore the correlation between the incidence of atrial fibrillation (AF) and thyroid dysfunction in patients with hypertrophic obstructive cardiomyopathy (HOCM).MethodsThyroid function testing in 755 consecutive patients with HOCM were examined at the National Center for Cardiovascular Diseases (China) from October 2009 to December 2013. Patients were divided into four groups according to the TSH levels: TSH10.00mIU/L(n=17).ResultsA total of 107 patients were diagnosed with AF (14%).(1) Compared to HOCM patients without AF,HOCM patients with AF have older age (PConclusionOur results suggested that thyroid dysfunction was associated with an increased risk of AF in patients with HOCM.

Published
2022

2. Assessment of causal association between thyroid function and lipid metabolism: a Mendelian randomization study

Author

Jing-Jia, Wang, Zhen-Huang, Zhuang, Chun-Li, Shao, Can-Qing, Yu, Wen-Yao, Wang, Kuo, Zhang, Xiang-Bin, Meng, Jun, Gao, Jian, Tian, Ji-Lin, Zheng, Tao, Huang, and Yi-Da, Tang

Subjects
Thyroxine, Thyroid Gland, Thyrotropin, Triiodothyronine, Mendelian Randomization Analysis, Thyroid Function Tests, Lipid Metabolism
Abstract

Thyroid dysfunction is associated with cardiovascular diseases. However, the role of thyroid function in lipid metabolism remains partly unknown. The present study aimed to investigate the causal association between thyroid function and serum lipid metabolism via a genetic analysis termed Mendelian randomization (MR).The MR approach uses a genetic variant as the instrumental variable in epidemiological studies to mimic a randomized controlled trial. A two-sample MR was performed to assess the causal association, using summary statistics from the Atrial Fibrillation Genetics Consortium (n = 537,409) and the Global Lipids Genetics Consortium (n = 188,577). The clinical measures of thyroid function include thyrotropin (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels, FT3:FT4 ratio and concentration of thyroid peroxidase antibodies (TPOAb). The serum lipid metabolism traits include total cholesterol (TC) and triglycerides, high-density lipoprotein, and low-density lipoprotein (LDL) levels. The MR estimate and MR inverse variance-weighted method were used to assess the association between thyroid function and serum lipid metabolism.The results demonstrated that increased TSH levels were significantly associated with higher TC (β = 0.052, P = 0.002) and LDL (β = 0.041, P = 0.018) levels. In addition, the FT3:FT4 ratio was significantly associated with TC (β = 0.240, P = 0.033) and LDL (β = 0.025, P = 0.027) levels. However, no significant differences were observed between genetically predicted FT4 and TPOAb and serum lipids.Taken together, the results of the present study suggest an association between thyroid function and serum lipid metabolism, highlighting the importance of the pituitary-thyroid-cardiac axis in dyslipidemia susceptibility.

Published
2021

3. Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study.

Author

Jing-Jia WANG, Zhen-Huang ZHUANG, Can-Qing YU, Wen-Yao WANG, Wen-Xiu WANG, Kuo ZHANG, Xiang-Bin MENG, Jun GAO, Jian TIAN, Ji-Lin ZHENG, Jie YANG, Tao HUANG, Chun-Li SHAO, and Yi-Da TANG

Subjects
THYROID gland physiology, CARDIOVASCULAR diseases risk factors, THYROTROPIN, HYPERTENSION, GENETICS, GENETIC mutation, STROKE, CONFIDENCE intervals, THYROXINE, MYOCARDIAL ischemia, HEALTH status indicators, MYOCARDIAL infarction, METABOLIC disorders, HYPERLIPIDEMIA, TYPE 2 diabetes, PULMONARY heart disease, MOLECULAR epidemiology, ODDS ratio, CAUSALITY (Physics), HEART failure, DISEASE risk factors
Abstract

BACKGROUND Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardiovascular metabolism. However, the causal relationship of thyroid function and cardiometabolic health remains partly unknown. METHODS The Mendelian randomization (MR) was used to test genetic, potentially causal relationships between instrumental variables and cardiometabolic traits. Genetic variants of free thyroxine (FT4) and thyrotropin (TSH) levels within the reference range were used as instrumental variables. Data for genetic associations with cardiometabolic diseases were acquired from the genome-wide association studies of the FinnGen, CARDIoGRAM and CARDIoGRAMplusC4D, CHARGE, and MEGASTROKE. This study was conducted using summary statistic data from large, previously described cohorts. Association between thyroid function and essential hypertension (EHTN), secondary hypertension (SHTN), hyperlipidemia (HPL), type 2 diabetes mellitus (T2DM), ischemic heart disease (IHD), myocardial infarction (MI), heart failure (HF), pulmonary heart disease (PHD), stroke, and non-rheumatic valve disease (NRVD) were examined. RESULTS Genetically predicted FT4 levels were associated with SHTN (odds ratio = 0.48; 95% CI = 0.04-0.82, P = 0.027), HPL (odds ratio = 0.67; 95% CI = 0.18-0.88, P = 0.023), T2DM (odds ratio = 0.80; 95% CI = 0.42-0.86, P = 0.005), IHD (odds ratio = 0.85; 95% CI = 0.49-0.98, P = 0.039), NRVD (odds ratio = 0.75; 95% CI = 0.27-0.97, P = 0.039). Additionally, genetically predicted TSH levels were associated with HF (odds ratio = 0.82; 95% CI = 0.68-0.99, P = 0.042), PHD (odds ratio = 0.75; 95% CI = 0.32-0.82, P = 0.006), stroke (odds ratio = 0.95; 95% CI = 0.81-0.97, P = 0.007). However, genetically predicted thyroid function traits were not associated with EHTN and MI. CONCLUSIONS Our study suggests FT4 and TSH are associated with cardiometabolic diseases, underscoring the importance of the pituitary-thyroid-cardiac axis in cardiometabolic health susceptibility. [ABSTRACT FROM AUTHOR]

Published
2022
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