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Rapid and effective control of non‐compressible massive hemorrhage poses a great challenge in first‐aid and clinical settings. Herein, a biopolymer‐based powder is developed for the control of non‐compressible hemorrhage. The powder is designed to facilitate rapid hemostasis by its excellent hydrophilicity, great specific surface area, and adaptability to the shape of wound, enabling it to rapidly absorb fluid from the wound. Specifically, the powder can undergo sequential cross‐linking based on "click" chemistry and Schiff base reaction upon contact with the blood, leading to rapid self‐gelling. It also exhibits robust tissue adhesion through covalent/non‐covalent interactions with the tissues (adhesive strength: 89.57 ± 6.62 KPa, which is 3.75 times that of fibrin glue). Collectively, this material leverages the fortes of powder and hydrogel. Experiments with animal models for severe bleeding have shown that it can reduce the blood loss by 48.9%. Studies on the hemostatic mechanism also revealed that, apart from its physical sealing effect, the powder can enhance blood cell adhesion, capture fibrinogen, and synergistically induce the formation of fibrin networks. Taken together, this hemostatic powder has the advantages for convenient preparation, sprayable use, and reliable hemostatic effect, conferring it with a great potential for the control of non‐compressible hemorrhage. [ABSTRACT FROM AUTHOR]

As a major cause for recurrent miscarriage and secondary infertility, intrauterine adhesion (IUA) is characterized by partial or total obliteration of the uterine cavity and/or cervical canal due to injuries to the basal layer of endometrium caused by improper intrauterine operation and/or infection. While various treatments have been used to prevent the occurrence of IUA, these approaches have shown limited therapeutic efficiency. As a promising bio-engineering method, tissue engineering technology may be used for enhancing endometrial regeneration. Extracellular matrix such as small intestine submucosa (SIS) may provide a favorable microenvironment, whilst stem cells can promote the endometrial regenerative capacity. In this study, genipin-crosslinked SIS (GP-SIS) loaded with urine-derived stem cells (USCs) has been applied for the regeneration of endometrium. The GP-SIS scaffolds have demonstrated sound mechanical properties and excellent biocompatibility and promoted epithelial migration and angiogenesis in vitro. In a rat model for IUA caused by endometrial damage, transplantation of the GP-SIS/USCs has maintained normal luminal structure, promoted endometrial and glandular regeneration, vascularization, inhibited fibrogenesis and improved endometrial receptivity. Our research has therefore provided a new strategy for promoting the recovery of endometrial structure and function, which may be beneficial for the prevention and treatment of IUA in the clinics. [Display omitted] [ABSTRACT FROM AUTHOR]