1. In vivo preclinical cancer and tissue engineering applications of absolute oxygen imaging using pulse EPR.
- Author
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Epel B, Kotecha M, and Halpern HJ
- Subjects
- Animals, Humans, Oxygen chemistry, Reproducibility of Results, Electron Spin Resonance Spectroscopy methods, Molecular Imaging methods, Neoplasms diagnostic imaging, Tissue Engineering methods
- Abstract
The value of any measurement and a fortiori any measurement technology is defined by the reproducibility and the accuracy of the measurements. This implies a relative freedom of the measurement from factors confounding its accuracy. In the past, one of the reasons for the loss of focus on the importance of imaging oxygen in vivo was the difficulty in obtaining reproducible oxygen or pO
2 images free from confounding variation. This review will briefly consider principles of electron paramagnetic oxygen imaging and describe how it achieves absolute oxygen measurements. We will provide a summary review of the progress in biomedical EPR imaging, predominantly in cancer biology research, discuss EPR oxygen imaging for cancer treatment and tissue graft assessment for regenerative medicine applications., (Copyright © 2017. Published by Elsevier Inc.)- Published
- 2017
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