1. Chronic toxicological effects of β‐diketone antibiotics on Zebrafish (Danio rerio) using transcriptome profiling of deep sequencing
- Author
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Wang, Huili, Yin, Xiaohan, Li, Fanghui, Dahlgren, Randy A, Zhang, Yuna, Zhang, Hongqin, and Wang, Xuedong
- Subjects
Genetics ,Biotechnology ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Good Health and Well Being ,Animals ,Anti-Bacterial Agents ,Down-Regulation ,Gene Expression Profiling ,High-Throughput Nucleotide Sequencing ,Ketones ,Liver ,Microscopy ,Electron ,Sequence Analysis ,RNA ,Transcriptome ,Up-Regulation ,Zebrafish ,transcriptome ,beta-diketone antibiotics ,zebrafish ,deep sequencing ,immune system ,β-diketone antibiotics ,Toxicology - Abstract
Transcriptome analysis is important for interpreting the functional elements of the genome and revealing the molecular constituents of cells and tissues. Herein, differentially transcribed genes were identified by deep sequencing after zebrafish (Danio rerio) were exposed to β-diketone antibiotics (DKAs); 23,129 and 23,550 mapped genes were detected in control and treatment groups, a total of 3238 genes were differentially expressed between control and treatment groups. Of these genes, 328 genes (213 up- and 115 down-regulation) had significant differential expression (p < 0.05) and an expression ratio (control/treatment) of >2 or
- Published
- 2016