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We developed Mixed Matrix Membrane Adsorbers (MMMAs) formed by cellulose acetate and various sorbent particles (activated carbon, zeolites ZSM-5 and clinoptilolite) for the removal of urea, creatinine and uric acid from aqueous solutions, to be used in the regeneration of spent dialysate water from Hemodialysis (HD). This process would allow reducing the disproportionate amount of water consumed and permits the development of closed-loop HD devices, such as wearable artificial kidneys. The strategy of MMMAs is to combine the high permeability of porous membranes with the toxin-capturing ability of embedded particles. The water permeability of the MMMAs ranges between 600 and 1500 L/(h m2 bar). The adsorption of urea, the limiting toxin, can be improved of about nine times with respect to the pure cellulose acetate membrane. Flow experiments demonstrate the feasibility of the process in a real HD therapy session.

Torlon® is a thermally and plasticization-resistant polyamide imide characterized by low gas permeability at room temperature. In this work, we aimed at improving the polymer performance in the thermally-enhanced He/CO2 and H2/CO2 separations, by compounding Torlon® with a highly permeable filler, ZIF-8, to fabricate Mixed Matrix Membranes (MMMs). The effect of filler loading, gas size, and temperature on the MMMs permeability, diffusivity, and selectivity was investigated. The He permeability increased by a factor of 3, while the He/CO2 selectivity decreased by a factor of 2, when adding 25 wt % of ZIF-8 at 65 °C to Torlon®; similar trends were observed for the case of H2. The MMMs permeability and size-selectivity were both enhanced by temperature. The behavior of MMMs is intermediate between the pure polymer and pure filler ones, and can be described with models for composites, indicating that such materials have a good polymer/filler adhesion and their performance could be tailored by acting on the formulation. The behavior observed is in line with previous investigations on MMMs based on glassy polymers and ZIF-8, in similar conditions, and indicates that ZIF-8 can be used as a polymer additive when the permeability is a controlling aspect, with a proper choice of loading and operative temperature.

Mixed Matrix Membrane Adsorbers (MMMAs) based on Cellulose Acetate (CA) were prepared and tested for the removal of uremic toxins from spent dialysate aqueous streams from hemodialysis treatments. MMMAs were fabricated and modified with a natural zeolite, ZUF, to enhance the affinity towards urea, creatinine and uric acid. Water permeability tests and batch adsorption tests were performed on the prepared MMMAs, obtaining encouraging results. The removal capacity of the pure CA membranes is improved after addition of ZUF by factors as high as 83% for urea and up to 28% for creatinine.