1. The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics.
- Author
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Weber, Lukas M., Divecha, Heena R., Tran, Matthew N., Sang Ho Kwon, Spangler, Abby, Montgomery, Kelsey D., Tippani, Madhavi, Bharadwaj, Rahul, Kleinman, Joel E., Page, Stephanie C., Hyde, Thomas M., Collado-Torres, Leonardo, Maynard, Kristen R., Martinowich, Keri, and Hicks, Stephanie C.
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LOCUS coeruleus , *TRANSCRIPTOMES , *GENE expression , *ALZHEIMER'S disease , *CENTRAL nervous system , *PARKINSON'S disease - Abstract
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning, and memory. The LC-NE system is also implicated in multiple neurological and neuropsychiatric disorders. Importantly, LC-NE neurons are highly sensitive to degeneration in both Alzheimer's and Parkinson's disease. Despite the clinical importance of the brain region and the prominent role of LC-NE neurons in a variety of brain and behavioral functions, a detailed molecular characterization of the LC is lacking. Here, we used a combination of spatially-resolved transcriptomics and single-nucleus RNA-sequencing to characterize the molecular landscape of the LC region and the transcriptomic profile of LC-NE neurons in the human brain. We provide a freely accessible resource of these data in web-accessible and downloadable formats. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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