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Your search keyword '"Qasim, Mohd"' showing total 3 results
Start Over Author "Qasim, Mohd" Topic transmission electron microscopy
3 results on '"Qasim, Mohd"'

1. Synthesis and characterization of neem gum coated superparamagnetic nanoparticle based novel nanobiocomposite.

Author

Asghar, Khushnuma, Qasim, Mohd, and Das, Dibakar

Subjects
*NEEM, *TARGETED drug delivery, *CANCER cell growth, *TRANSMISSION electron microscopy, *MAGNETIC properties, *POLYSACCHARIDES
Abstract

Uses of biopolymers for the development of nanocarriers are receiving significant attention due to its biocompatible and biodegradable nature. Neem (Azadirachta indica) is a well known medicinal plant and it is reported that the polysaccharides and limonoids present in the neem extract prevent the growth and proliferation of cancer cells. In this work, we have synthesized neem gum (NG) coated Fe 3 O 4 nanoparticles (NPs) based novel nanobiocomposite (Fe 3 O 4 @NG NBC) by simple sonochemical method and characterized it for structural, microstructural and magnetic properties. The morphology, structure, and magnetic properties of the prepared Fe 3 O 4 NPs and Fe 3 O 4 @NG nanobiocomposite were investigated by X-ray diffractometer (XRD), Fourier-transform infrared (FTIR), Transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and vibrating sample magnetometer (VSM) analysis. XRD pattern, TEM micrograph and FTIR spectra confirmed the successful coating of neem gum on Fe 3 O 4 nanoparticles. IR spectra of Fe 3 O 4 @NG nanobiocomposite revealed the presence of specific bands corresponding to both neem gum and Fe 3 O 4 NPs, which confirmed the formation of Fe 3 O 4 @NG NBC. The obtained size of Fe 3 O 4 @NG nanobiocomposite particles was ∼50–400 nm. VSM analysis confirmed the superparamagnetic nature of both Fe 3 O 4 NPs and Fe 3 O 4 @NG nanobiocomposite. Fe 3 O 4 @NG nanobiocomposite was loaded with anticancer drug doxorubicin (Dox) and its release behaviour was studied at pH 7.4 and 5. Faster release of Dox was observed in acidic environment. In vitro cytotoxicity of the prepared Fe 3 O 4 @NG NBC against human monocytic cell line THP‐1 was also studied by MTT assay. This novel Fe 3 O 4 @NG nanobiocomposite with low toxicity, biodegradability, water dispersability, excellent drug loading ability and good magnetic controllability could offer potential applications in biomedical field including targeted drug delivery for cancer diagnosis and treatment in near future. [ABSTRACT FROM AUTHOR]

Published
2019
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2. One-Pot Green Synthesis of Carbon Quantum Dot for Biological Application.

Author

Asghar, Khushnuma, Qasim, Mohd, and Das, D.

Subjects
*QUANTUM dots, *BIOMEDICAL materials, *TRANSMISSION electron microscopy, *PARTICLE size determination, *CHEMICAL synthesis
Abstract

A one-pot microwave assisted method for synthesizing carbon quantum dots (CQDs) from honey is presented in this paper. The structural, morphological and optical properties of synthesized CQDs were characterized by XRD, TEM, UV-Vis spectrophotometer, and Raman techniques. The average particle size of CQDs is found to be 2 to 7 nm. The main advantage of this work is the use of inexpensive, less toxic and environmental friendly precursors and synthesis procedure for CQDs. In addition to this, the particle size of prepared CQDs was found to be ultrafine with narrow size distribution. The as-prepared CQDs, with smaller particle size, good stability, good optical properties, water dispersibility and low toxicity, show promising potential for applications in biomedical field. [ABSTRACT FROM AUTHOR]

Published
2017
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3. Facile Synthesis of Fe3O4 and multifunctional Fe3O4@Albumen Nanoparticles for Biomedical Applications.

Author

Qasim, Mohd, Asghar, Khushnuma, and Das, Dibakar

Subjects
*IRON oxide nanoparticles, *IRON oxide synthesis, *BIOMEDICAL materials, *TRANSMISSION electron microscopy, *SURFACE coatings
Abstract

In this work two different sizes of Fe3O4 nanoparticles (NPs) have successfully been synthesized by changing reaction parameter. Prepared Fe3O4 NPs have been characterized for its structural, morphological, and magnetic properties by using XRD, FESEM, TEM, SAED and VSM techniques. XRD and SAED patterns confirmed the formation of cubic phase Fe3O4 NPs. Crystallite sizes estimated using the Debye-Scherrer equation of both prepared Fe3O4 NPs using less (S1) and more (S2) NaBH4 were found to be ~9 and ~18 nm respectively. Both TEM and FESEM results suggested nearly spherical and random morphology of both S1 and S2 prepared Fe3O4 NPs with average particles sizes of 22 and 27 nm respectively. VSM result revealed superparamagnetic nature of the prepared Fe3O4 NPs. In the last section of this work, prepared Fe3O4 NPs have successfully been coated with albumen to form biocompatible multifunctional Fe3O4@Alb nanoparticle. These Fe3O4@Alb NPs may find potential applications in targeted drug delivery due to its magnetic tunability, biocompatibility and inexpensiveness. [ABSTRACT FROM AUTHOR]

Published
2017
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