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Vesicular particles based on inclusion complexes between BPB and γ-HB-β-CDs were prepared and characterized for the first time. The morphologies and sizes were confirmed by transmission electron microscopy (TEM), scanning electron microscope (SEM), and dynamic light scattering (DLS). Particularly, these vesicular particles exhibiting clearly fluorescent dots observed by laser confocal scanning microscopy (LCSM) could be alternative candidates as fluorescent probes and labels being applied to cellular staining, labeling, bio-mimicking and drug delivery. The ultraviolet, fluorescence, and nuclear magnetic resonance (NMR) measurements confirmed the existence of stable 1:1 BPB-γ-HB-β-CD complexes in the system. The vesicular particles were assumed to be constructed by orderly self-aggregates of these inclusion complexes. [ABSTRACT FROM AUTHOR]

A new amphiphilic cyclodextrin derivative 2-O-(hydroxypropyl-N,N-dimethyl-N-dodecylammonio)-β-cyclodextrin (2-HPDMDA-β-CD) was prepared and characterized by surface tension, electrical conductivity, dynamic light scattering, transmission electron microscopy (TEM) and steady-state fluorescence. 2-HPDMDA-β-CD was found to be a fine surfactant with a smaller critical micelle concentration (1.21 mM) value than that of dodecyltrimethylammonium chloride. TEM showed that 2-HPDMDA-β-CD could form two kinds of spherical aggregates in solution. The smaller one showed little concentration dependence while the larger one showed relatively strong concentration dependence. 2-HPDMDA-β-CD could be a fine host compound in molecular recognition with two functional spaces of the cyclodextrin cavity and micelles. [ABSTRACT FROM AUTHOR]

Abstract: Redox-responsive vesicles self-assembled by supramolecular cyclodextrin amphiphiles, consisting of the guest (N-1-decyl-ferrocenylmethylamine, 1) and the host (2-O-carboxymethyl-β-cyclodextrin, CM-β-CD), were prepared. The morphologies and sizes of these novel vesicles in an aqueous solution were observed by transmission electron microscopy (TEM) and were confirmed by atomic force microscopy (AFM) and dynamic light scattering (DLS) measurements. The effects of the host–guest ratio, the concentration and the solvent composition of water and methanol on vesicles were investigated in detail. The interactions between the host and the guest, the complex stoichiometry, the stability constant and conformations of 1·CM-β-CD in aqueous solution were investigated by cyclic voltammetry (CV), UV and nuclear magnetic resonance (NMR) measurements. According to the complex stoichiometry and ‘tadpole-like’ spatial conformations, the supramolecular cyclodextrin amphiphiles made from 1·CM-β-CD were proposed to form the membranes of the vesicles. This kind of vesicle system was responsive to an oxidizing agent, which could pave the way to combine supramolecular host–guest chemistry and membrane chemistry for potentially functional applications. [Copyright &y& Elsevier]