4 results on '"Benning, Louise"'
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2. Impact of deceased-donor characteristics on early graft function: outcome of kidney donor pairs accepted for transplantation.
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Mahler, Christoph F., Friedl, Felix, Nusshag, Christian, Speer, Claudius, Benning, Louise, Göth, Daniel, Schaier, Matthias, Sommerer, Claudia, Mieth, Markus, Mehrabi, Arianeb, Renders, Lutz, Heemann, Uwe, Krautter, Markus, Schwenger, Vedat, Echterdiek, Fabian, Zeier, Martin, Morath, Christian, and Kälble, Florian
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GENERALIZED estimating equations ,GRAFT survival ,GLOMERULAR filtration rate ,BODY mass index ,KIDNEY transplantation - Abstract
Introduction: The impact of deceased donor characteristics on kidney transplant outcomes is controversial. Correspondingly, the predictive performance of deceased donor scores remains moderate, and many transplant centers lack validated criteria for graft acceptance decisions. To better dissect donor-related risk from recipient and periprocedural variables, we analyzed outcomes of kidney donor pairs transplanted in different individuals. Methods: This study explored (a)symmetry of early outcomes of 328 cadaveric kidney transplant recipients from 164 donor pairs transplanted at three Eurotransplant centers. The primary discriminatory factor was (a)symmetry of partner graft function, defined as early graft loss or impaired graft function [estimated glomerular filtration rate (eGFR) <30 mL/min] 3 months after transplantation. We reasoned that a relevant impact of donor factors would result in a high concordance rate of limited graft function or failure. Results: The observed number of symmetric graft failure after transplantation was less than statistically expected (3 months: 1 versus 2, p = 0.89; and 12 months: 3 versus 5, p = 0.26). However, we found a trend toward an impaired 5-year graft survival of grafts with good function 3 months after transplantation but a failed or impaired partner graft compared to symmetrically well-functioning grafts (p = 0.09). Subsequently, we explored the impact of individual donor and recipient variables on early transplant outcomes. Generalized estimating equations after feature selection with LassoGEE bootstrap selected donor age, donor body mass index, and donor eGFR as the relevant risk factors. Discussion: Our findings indicate that donor factors impact early outcomes in kidney transplantation but may have a limited role in long-term graft survival, once a graft has been accepted for transplantation. Utilizing donor-based clinical scores has the potential to aid clinicians in acceptance decisions, giving them an estimate of individual posttransplant outcomes. However, the ultimate decision for acceptance should rest with clinicians, who must consider the complex interplay of donor factors, as well as recipient and periprocedural characteristics. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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3. Neutralizing antibody response against the B.1.617.2 (delta) and the B.1.1.529 (omicron) variants after a third mRNA SARS-CoV-2 vaccine dose in kidney transplant recipients
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Louise Benning, Christian Morath, Marie Bartenschlager, Heeyoung Kim, Marvin Reineke, Jörg Beimler, Mirabel Buylaert, Christian Nusshag, Florian Kälble, Paula Reichel, Maximilian Töllner, Matthias Schaier, Katrin Klein, Vladimir Benes, Tobias Rausch, Susanne Rieger, Maximilian Stich, Burkhard Tönshoff, Niklas Weidner, Paul Schnitzler, Martin Zeier, Caner Süsal, Thuong Hien Tran, Ralf Bartenschlager, Claudius Speer, Süsal, Caner (ORCID 0000-0003-2521-8201 & YÖK ID 351800), Benning, Louise, Morath, Christian, Bartenschlager, Marie, Kim, Heeyoung, Reineke, Marvin, Beimler, Jorg, Buylaert, Mirabel, Nusshag, Christian, Kaelble, Florian, Reichel, Paula, Toellner, Maximilian, Schaier, Matthias, Klein, Katrin, Benes, Vladimir, Rausch, Tobias, Rieger, Susanne, Stich, Maximilian, Toenshoff, Burkhard, Weidner, Niklas, Schnitzler, Paul, Zeier, Martin, Tran, Thuong Hien, Bartenschlager, Ralf, Speer, Claudius, Koç University Hospital, and School of Medicine
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Vaccines, Synthetic ,Transplantation ,COVID-19 Vaccines ,SARS-CoV-2 ,Clinical decision-making ,Clinical research ,Immune modulation ,Immunosuppression ,Kidney transplantation ,Nephrology ,Practice ,Solid organ transplantation ,Vaccine ,COVID-19 ,Antibodies, Viral ,Antibodies, Neutralizing ,Kidney Transplantation ,Surgery ,Transplant Recipients ,Viral Envelope Proteins ,Immunoglobulin G ,Humans ,Immunology and Allergy ,Pharmacology (medical) ,RNA, Messenger ,mRNA Vaccines - Abstract
Seroconversion after COVID-19 vaccination is impaired in kidney transplant recipients. Emerging variants of concern such as the B.1.617.2 (delta) and the B.1.1.529 (omicron) variants pose an increasing threat to these patients. In this observational cohort study, we measured anti-S1 IgG, surrogate neutralizing, and anti-receptor-binding domain antibodies three weeks after a third mRNA vaccine dose in 49 kidney transplant recipients and compared results to 25 age-matched healthy controls. In addition, vaccine-induced neutralization of SARS-CoV-2 wild-type, the B.1.617.2 (delta), and the B.1.1.529 (omicron) variants was assessed using a live-virus assay. After a third vaccine dose, anti-S1 IgG, surrogate neutralizing, and anti-receptor-binding domain antibodies were significantly lower in kidney transplant recipients compared to healthy controls. Only 29/49 (59%) sera of kidney transplant recipients contained neutralizing antibodies against the SARS-CoV-2 wild-type or the B.1.617.2 (delta) variant and neutralization titers were significantly reduced compared to healthy controls (p < 0.001). Vaccine-induced cross-neutralization of the B.1.1.529 (omicron) variants was detectable in 15/35 (43%) kidney transplant recipients with seropositivity for anti-S1 IgG, surrogate neutralizing, and/or anti-RBD antibodies. Neutralization of the B.1.1.529 (omicron) variants was significantly reduced compared to neutralization of SARS-CoV-2 wild-type or the B.1.617.2 (delta) variant for both, kidney transplant recipients and healthy controls (p < .001 for all)., Dietmar Hopp Stiftung; Heidelberg Faculty of Medicine Rahel Goitein-Straus Program; Heidelberg Faculty of Medicine Physician Scientist Program; German Federal Research Network Applied Surveillance and Testing (BFAST); Network University Medicine; Helmholtz Association Initiative and Networking Fund Project Virological and Immunological Determinants of COVID-19 Pathogenesis
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- 2022
4. Neutralization of SARS-CoV-2 Variants of Concern in Kidney Transplant Recipients after Standard COVID-19 Vaccination
- Author
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Louise Benning, Christian Morath, Marie Bartenschlager, Christian Nusshag, Florian Kälble, Mirabel Buylaert, Matthias Schaier, Jörg Beimler, Katrin Klein, Julia Grenz, Paula Reichel, Asa Hidmark, Gerald Ponath, Maximilian Töllner, Marvin Reineke, Susanne Rieger, Burkhard Tönshoff, Paul Schnitzler, Martin Zeier, Caner Süsal, Ralf Bartenschlager, Claudius Speer, Süsal, Caner (ORCID 0000-0003-2521-8201 & YÖK ID 351800), Benning, Louise, Morath, Christian, Bartenschlager, Marie, Nusshag, Christian, Kalble, Florian, Buylaert, Mirabel, Schaier, Matthias, Beimler, Jorg, Klein, Katrin, Grenz, Julia, Reichel, Paula, Hidmark, Asa, Ponath, Gerald, Tollner, Maximilian, Reineke, Marvin, Rieger, Susanne, Tonshoff, Burkhard, Schnitzler, Paul, Zeier, Martin, Bartenschlager, Ralf, Speer, Claudius, and School of Medicine
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Adult ,Male ,Transplantation ,COVID-19 ,SARS-CoV-2 ,Kidney transplantation ,Variants of concern ,Vaccination ,COVID-19 Vaccines ,Epidemiology ,Middle Aged ,Critical Care and Intensive Care Medicine ,Kidney Transplantation ,Urology and nephrology ,Editorial ,Nephrology ,Humans ,Female ,Prospective Studies - Abstract
Background and objectives: antibody response after severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) vaccination is impaired in kidney transplant recipients. Emerging variants, such as B.1.617.2 ( d), are of particular concern because of their higher transmissibility and partial immune escape. Little is known about protection against these variants in immunocompromised patients. Design, setting, participants, and measurements: in this prospective two-center study, antispike 1 IgG and surrogate neutralizing antibodies were measured in 173 kidney transplant recipients and 166 healthy controls with different vaccination schedules. In addition, different SARS-CoV-2 epitope antibodies from 135 vaccinated kidney transplant recipients were compared with antibodies in 25 matched healthy controls after second vaccination. In 36 kidney transplant recipients with seroconversion, neutralization against B.1.1.7 ( a), B.1.351 ( b), and B.1.617.2 ( d) was determined on VeroE6 cells and compared with neutralization in 25 healthy controls. Results: kidney transplant recipients had significantly lower seroconversion rates compared with healthy controls. After the second vaccination, antispike 1, antireceptor-binding domain, and surrogate neutralizing antibodies were detectable in 30%, 27%, and 24% of kidney transplant recipients, respectively. This compares with 100%, 96%, and 100% in healthy controls, respectively (P,0.001). Neutralization against B.1.1.7 was detectable in all kidney transplant recipients with seroconversion, with a median serum dilution that reduces infection of cells by 50% of 80 (interquartile range, 80-320). In contrast, only 23 of 36 (64%) and 24 of 36 (67%) kidney transplant recipients showed neutralization against B.1.351 and B.1.617.2, respectively, with median serum dilutions that reduce infection of cells by 50% of 20 (interquartile range, 0-40) and 20 (interquartile range, 0-40), respectively. Neutralization against different variants was significantly higher in healthy controls (P,0.001), with all patients showing neutralization against all tested variants. Conclusions: seroconverted kidney transplant recipients show impaired neutralization against emerging variants of concern after standard two-dose vaccination., Dietmar Hopp Stiftung; German Federal Research Network Applied Surveillance and Testing; Network University Medicine; fightCOVID@DKFZ Initiative; Helmholtz Association Initiative and Networking Fund Project Virological and Immunological Determinants of COVID-19 Pathogenesis; Lessons to Get Prepared for Future Pandemics; Heidelberg Faculty of Medicine Rahel Goitein-Strauss Program; Heidelberg Faculty of Medicine Physician Scientist Program
- Published
- 2022
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