1. [Decellularization of organs and tissues].
- Author
-
Startseva OI, Sinelnikov ME, Babayeva YV, and Trushenkova VV
- Subjects
- Allografts cytology, Graft Rejection immunology, Plastic Surgery Procedures, Tissue Scaffolds, Allografts immunology, Cells immunology, Tissue Engineering methods, Transplantation Immunology immunology, Transplantation, Homologous methods
- Abstract
The use of allogenic materials in reconstructive surgery is of great scientific interest due to high availability of donor tissues. The positive aspects of allogenous tissue transplantation are complicated by the histological incompatibility of donor tissue and recipient organism. This incompatibility results hypersensitivity reaction towards the allogenous transplant followed by rejection of allogenic tissue and even death in some cases. Cellular biological incompatibility may be managed by decellularization of allogenous organs and tissues prior to transplantation. The improvement of decellularization techniques will facilitate application of allogenous tissues in complex reconstructive procedures and significantly increase the capabilities of reconstructive surgery.
- Published
- 2019
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