1. Interferon Alpha for Refractory Pseudophakic Cystoid Macular Edema (Irvine-Gass Syndrome).
- Author
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Dimopoulos, Spyridon, Deuter, Christoph M. E., Blumenstock, Gunnar, Zierhut, Manfred, Dimopoulou, Anastasia, Voykov, Bogomil, Bartz-Schmidt, Karl-Ulrich, and Doycheva, Deshka
- Subjects
RETINAL degeneration ,RETINA ,INJECTIONS ,RETROSPECTIVE studies ,ANTINEOPLASTIC agents ,TREATMENT effectiveness ,SYMPTOMS ,VISUAL acuity ,ANGIOGRAPHY ,DISEASE complications - Abstract
Purpose: To assess the efficacy and safety of systemic interferon alpha-2a (IFN) for refractory pseudophakic cystoid macular edema (PCME).Methods: Retrospective observational study. The primary outcome was the decrease of central retinal thickness (CRT). Secondary endpoints were the improvement of best-corrected visual acuity (BCVA) and the assessment of IFN-related side effects.Results: Twenty-four eyes of 20 patients were included. The median CRT was 513 µm (range 220-980 µm) at baseline and decreased to 190 µm (range 140-520 µm) at the last follow-up visit (p < 0.001). Reduction of CRT greater than 100 µm was observed in 22 eyes (92%). The median BCVA (logMAR) increased statistically significant from 0.5 (range 0.2-1.5) at baseline to 0.3 (0-0.8) at the last follow-up (p < 0.001). The BCVA improved in 18 eyes (75%) and remained stable in five eyes (21%). No severe treatment-related side effects occurred.Conclusion: IFN is a very effective agent for treatment of refractory PCME. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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